Secondary Hyperparathyroidism Clinical Trial
Official title:
Providing Intravenous Paricalcitol Treatment to the Sick and Poor Chronic Hemodialysis Patients With Severe Secondary Hyperparathyroidism Resistant to Existing Vitamin D Analogs
This study aims to provide intravenous paritcalcitol treatment for the sick and poor
hemodialysis patients with severe secondary hyperparathyroidism (SHPT) resistant to existing
vitamin D analogs therapy or with hypercalcemia precluding the use of existing vitamin D
analogs.
The study aims to evaluate the effect of paricalcitol on control of SHPT, biochemical
parameters of chronic kidney disease-mineral bone disease, cardiac parameters, vascular
calcification and stiffness parameters and nutrition status in patients receiving chronic
hemodialysis treatment.
This is a 2-year single-arm intervention study of which intravenous paricalcitol will be
provided as a second-line treatment to 30 chronic hemodialysis patients with severe SHPT
(defined as intact parathyroid hormone [iPTH] ≥ 800pg/mL) resistant to existing vitamin D
analogs treatment (including rocaltrol and alfacalcidol) or with hypercalcemia (defined as
serum calcium ≥2.56mmol/L) precluding the use of existing vitamin D analogs.
The study aims to evaluate the control of SHPT, various biochemical parameters of chronic
kidney disease-mineral bone disease, left ventricular mass and volumes, vascular
calcification and stiffness parameters, handgrip strength and serum albumin with the use of
intravenous paricalcitol in patients receiving chronic hemodialysis treatment.
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