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Seach Results for — “breast cancer”

Identifying Circulating Breast Cancer Cells in Women With Metastatic Breast Cancer

A Feasibility Study of a Novel Technique to Identify Circulating Breast Cancer Cells in Patients With Metastatic Breast Cancer

RATIONALE: Studying samples of blood and pleural or peritoneal fluid from patients with metastatic breast cancer in the laboratory may help doctors identify biomarkers related to breast cancer and learn more about how breast cancer begins and spreads in the body. PURPOSE: This research study is looking at a new way of identifying circulating breast cancer cells in blood and in pleural or peritoneal fluid in women with metastatic breast cancer.

NCT00897338 — Breast Cancer
Status: Completed
http://inclinicaltrials.com/breast-cancer/NCT00897338/

Breast Cancer Education to Prisoner Women

The Effect of Breast Cancer Education Given to Prisoner Women on Breast Cancer Knowledge and Awareness

The aim of the study is to determine the effect of breast cancer education given to incarcerated women on breast cancer knowledge and awareness.

NCT06455657 — Breast Cancer
Status: Recruiting
http://inclinicaltrials.com/breast-cancer/NCT06455657/

Frequency of Occult Breast Cancer After Prophylactic Mastectomy Among High-Penetrance Breast Cancer Gene Positives - OBC-PM

Frequency of Occult Breast Cancer After Prophylactic Mastectomy Among High-Penetrance Breast Cancer Gene Positives; Future Implications on Sentinel Lymph Node Biopsy in LMIC: A Single-center Cross-sectional Study

The role of Sentinel Lymph Node Biopsy(SLNB) among mutation-negative BC patients is well established; however, we are lacking data to assess the role of sentinel lymph node biopsy for patients who are undergoing surgery for prophylactic reasons without proven malignancy. Literature has reported a positive Occult Breast Cancer (OBC) rate of 0 to 11.3% among mastectomy specimens which are removed prophylactically. Majority of the time when the invasive focus is diagnosed in prophylactic mastectomy specimens they are found to be in-situ cases where axillary Staging using SLNB can be exempted; however, when the OBC is identified even in prophylactic mastectomy specimens, axilla should be addressed accordingly. Albeit SLNB has associated complications with it; postoperative pain, lymphedema, paresthesia and rare reaction to the injected dye. Therefore the question here arises regarding skipping SLNB among patients who are undergoing PRRMs without proven malignancy pre-operatively. However, before standardizing the practice in our population we need convincing evidence that the frequency of OBC is low among our patients. By identifying the true prevalence of OBC among our gene-positive HBC patients who are opting for PRRM, we would be able to skip SLNB; as not only it has psychological implications but also adds a financial burden on patients and families due to the addition of an extra procedure and hospital bills; as the financial and socioeconomic status of our population has already declined over last few years due to the economic crises faced worldwide, specifically after-affects are seen in Lower Middle-Income Country(LMIC) like Pakistan.

NCT05771454 — Breast Cancer
Status: Completed
http://inclinicaltrials.com/breast-cancer/NCT05771454/

MammoScreen Breast Cancer Risk Assessment and Decision Aid for Breast Cancer Screening and Referrals

Implementing USPSTF Recommendations for Breast Cancer Screening and Prevention by Integrating Clinical Decision Support Tools With the Electronic Health Record

This study collects information to implement MammoScreen for Breast Cancer Screening and Referrals. MammoScreen is a risk assessment questionnaire that identifies individuals at average and increased risk for breast cancer and guides their screening decisions.

NCT04996316 — Breast Carcinoma
Status: Recruiting
http://inclinicaltrials.com/breast-carcinoma/NCT04996316/

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast cAncer (IMBASSA) - IMBASSA

IMpact of BrcA Status on Survival in Adjuvant Breast Cancer (IMBASSA)

Relationship between the presence of the BRCA mutation (BReast Cancer) and outcomes is unclear in high-risk early breast cancers (BC). This study is a multi-center retrospective cohort of patients treated in region Franche-Comté for an early BC by neoadjuvant and/or adjuvant chemotherapy. The primary aim was to describe clinical and pathological characteristics considering BRCA mutated (BRCAm) patients versus BRCA wild type (BRCAwt) patients or untested patients. The second objective was to assess the prognostic impact of germinal BRCAm in this high-risk population.

NCT04012229 — Breast Cancer
Status: Completed
http://inclinicaltrials.com/breast-cancer/NCT04012229/

Bexarotene in Preventing Breast Cancer in Patients at High Risk for Breast Cancer

A Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer

This phase I trial studies the side effects and best dose of bexarotene in preventing breast cancer in patients at high risk for breast cancer. Bexarotene belongs to a class of drugs that are called rexinoids, and it may reduce the incidence of breast tumors.

NCT03323658 — Invasive Breast Carcinoma
Status: Completed
http://inclinicaltrials.com/invasive-breast-carcinoma/NCT03323658/

Genome Sequencing in Refractory Breast Cancer to Molecular Targeted Therapy and Young Breast Cancer

Genome Sequencing in Refractory Breast Cancer to Molecular Targeted Therapy and Young Breast Cancer

The purpose of this study is to investigate and analyse genomic profiles in patient with breast cancer who failed standard treatment, refractory and young breast cancer.

NCT02597179 — Breast Cancer
Status: Recruiting
http://inclinicaltrials.com/breast-cancer/NCT02597179/

Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer

Developing In-Vivo Models of Human Breast Cancer

RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.

NCT00897468 — Breast Cancer
Status: Completed
http://inclinicaltrials.com/breast-cancer/NCT00897468/

Sulindac in Preventing Breast Cancer in Women at High Risk for Breast Cancer

Phase IB Sulindac Study for Women at High Risk for Breast Cancer

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of sulindac may prevent breast cancer. PURPOSE: This randomized phase I trial is studying the effects of sulindac, to prevent breast cancer, in women at high risk for breast cancer.

NCT00245024 — Breast Cancer
Status: Completed
http://inclinicaltrials.com/breast-cancer/NCT00245024/

Tamoxifen in Preventing Breast Cancer in Women at Increased Risk for Breast Cancer

An Exploratory Study to Identify Potential Surrogate Endpoint Biomarkers That Are Modulated by Tamoxifen vs. Placebo in Women With an Increased Risk for Breast Cancer

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of tamoxifen may be effective in preventing breast cancer. PURPOSE: This randomized phase II trial is studying tamoxifen to see how well it works compared to placebo in preventing breast cancer in women who are at increased risk for the disease.

NCT00096369 — Breast Cancer
Status: Terminated
http://inclinicaltrials.com/breast-cancer/NCT00096369/