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Scar Prevention clinical trials

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NCT ID: NCT06312527 Active, not recruiting - Scar Prevention Clinical Trials

Mepiform in Simultaneous Bilateral TKA

Start date: March 7, 2024
Phase: N/A
Study type: Interventional

The goal of this RCT is comparing efficacy of silicone dressing in scar preventing after simultaneous bilateral total knee arthroplasty. The main question[s] it aims to answer are: - Does silicone dressing can prevent scar formation after total knee arthroplasty? - Does silicone dressing have similar functional outcomes and complications after total knee arthroplasty? Participants will apply silicone dressing after wound healed and apply for 10 weeks. Researchers will compare to the other side that is no intervention.

NCT ID: NCT04722705 Recruiting - Scar Prevention Clinical Trials

Combined Intense Pulsed Light (IPL) With Fractional Erbium:YAG Laser Ablation in Scar Prevention

Start date: January 6, 2020
Phase: N/A
Study type: Interventional

The scar site was divided into 3 sites; combined IPL/fractional Er:YAG laser treatment site, fractional Er:YAG laser treatment site and untreated control site. At baseline, three lesions were randomized to IPL / fractional Er:YAG laser combination therapy site, fractional Er:YAG laser treatment alone site, and untreated control site. The laser treatment was conducted total three sessions, immediately at suture removal (baseline), 4 weeks after suture removal and 8 weeks after suture removal. The evaluation of scar site was conducted 3 months later after last treatment (20 weeks after suture removal).

NCT ID: NCT04707131 Completed - Cicatrix Clinical Trials

A Study of Single Ascending Dose of LEM-S401 in Healthy Participants

Start date: July 11, 2022
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to assess the safety and tolerability of single dose of LEM-S401 in healthy adult subjects.

NCT ID: NCT01826942 Terminated - Scar Prevention Clinical Trials

Scar Prevention Using Fractional Carbon Dioxide Laser Treatment

Start date: January 2013
Phase: N/A
Study type: Interventional

In this study the investigators intend to determine the impact of fractional CO2 laser treatment on the edges of a fresh wound during surgical area closure on thin skin (e.g. face, hands, arms, thorax, etc.) and on thick skin (abdominoplasty procedure) on scar formation. The investigators will also evaluate the effect of shallow fractional laser treatment versus deep parameters settings. If effective treatments could be performed at time of surgery, this would result in both time and cost saving to the patient and to the healthcare system and will improve patient's self-image post surgeries.

NCT ID: NCT01780077 Completed - Cicatrix Clinical Trials

Evaluation of Safety, PK, and Preliminary Effects on Scar Formation of Multiple Intradermal Administrations of RXI-109

Start date: December 2012
Phase: Phase 1
Study type: Interventional

The purpose of this trial is to evaluate the safety and tolerability of multiple (3) intradermal doses of RXI-109 at small surgical incisions in the abdominal skin of healthy volunteers. The effect of RXI-109 versus placebo on scarring at these incision sites will be evaluated visually, histologically, and by biomarker analysis.

NCT ID: NCT01640912 Completed - Cicatrix Clinical Trials

Evaluation of the Safety, Pharmacokinetics, and Preliminary Effect on Scar Formation by RXI-109

Start date: June 2012
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to evaluate the safety and tolerability of a single intradermal administration of RXI-109 at small surgical incisions in the abdominal skin that will later be removed during an elective abdominoplasty. The effect of RXI-109 versus placebo on scarring at these incision sites will be evaluated visually and histologically.

NCT ID: NCT01038297 Completed - Scar Prevention Clinical Trials

Safety and Efficacy Study of Different Dose Levels of EXC 001 to Improve the Appearance of Scars in Subjects Undergoing Elective Abdominoplasty

Start date: December 1, 2009
Phase: Phase 2
Study type: Interventional

This study will compare how well EXC 001 works versus placebo in reducing the appearance of scars in subjects undergoing elective abdominoplasty. The study will also evaluate the safety of EXC 001 in healthy adult subjects.

NCT ID: NCT01037985 Completed - Scar Prevention Clinical Trials

Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars in Subjects Undergoing Elective Abdominoplasty

Start date: December 3, 2009
Phase: Phase 2
Study type: Interventional

This study will compare how well EXC 001 works versus placebo in reducing the appearance of scars in subjects undergoing elective abdominoplasty. The study will also evaluate the safety of EXC 001 in healthy adult subjects.

NCT ID: NCT01037413 Completed - Scar Prevention Clinical Trials

Safety and Efficacy Study of EXC 001 to Improve the Appearance of Scars From Prior Breast Surgery

Start date: December 22, 2009
Phase: Phase 2
Study type: Interventional

This study will compare how well EXC 001 works to improve the appearance of scars in subjects undergoing breast scar revision surgery. The study will also evaluate the safety of EXC 001 in healthy adult subjects.

NCT ID: NCT00892723 Completed - Scar Prevention Clinical Trials

A Study to Evaluate the Safety and Efficacy of Additional Doses of AZX100 Drug Product Following Excision of Keloid Scars

Start date: May 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study was to determine the safety of AZX100 Drug Product and to determine whether it was effective in preventing or reducing re-growth of surgically removed keloid scars.