Incorporating Avocados in Meals

Satiety Clinical Trial

Official title:

Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01271829
• Other study ID #: 5100220
• Status: Completed
• Phase: N/A
• First received: January 5, 2011
• Last updated: March 17, 2014
• Start date: January 2011
• Est. completion date: September 2012

Study information

• Verified date: March 2014
• Source: Loma Linda University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.

Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: September 2012
• Est. primary completion date: September 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 23 Years to 60 Years

Eligibility

Inclusion Criteria:

• 23-60 years old

• BMI 23-32

• Stable weight for 6 months

• Live or work near Loma Linda University

Exclusion Criteria:

• Smoker

• Heavy involvement in sports

• Dependent on caffeine

Study Design

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator)

Related Conditions & MeSH terms

• Gastrointestinal Peptides and Hormones
• Glycemic Index
• Insulin
• Satiety

Intervention

Dietary Supplement:
• Avocado supplement
Calories from avocados replace calories of the control lunch
• Avocado included
Calories from avocados will be added to calories from the control lunch

Locations

Country	Name	City	State
United States	Loma Linda University, Department of Nutrition	Loma Linda	California

Sponsors (2)

Lead Sponsor	Collaborator
Loma Linda University	Hass Avocado Board

Country where clinical trial is conducted

United States, 

References & Publications (1)

Wien M, Haddad E, Oda K, Sabaté J. A randomized 3×3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults. Nutr J. 2013 Nov 27;12:155. doi: 10 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Satiety	The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode	12 hours	No
Secondary	post-ingestion glycemic index	Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed.	3 hours	No
Secondary	insulin response	Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.	3 hours	No
Secondary	appetite-related gastrointestinal peptide and hormone release	Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed.	3 hours	No

External Links

•   Publication of study results