Gut Microbiota Clinical Trial
Official title:
Fat Quality and Blood Glucose
The overall aim is to investigate effects of saturated versus polyunsaturated fat on glycemic regulation and satiety in a postprandial study with healthy individuals. The potential effects will be related to changes in gut microbiota, the circulating levels of short chain fatty acids, inflammation and gene expression in peripheral mononuclear blood cells.
The intervention study will have a randomized, double blinded, cross-over design with
different test meals consisting of saturated or polyunsaturated fat. The amount of fat will
be identical in the test meals, but the fat quality will vary. The test meals are in the form
of muffin and spread.
All participants will consume two muffins and minimum 20 g of spread a day for three
consecutive days, consisting of either a high proportion of saturated fat or a high
proportion of polyunsaturated fat. At day one (visit 1 and 3) and day four (visit 2 and 4) of
the intervention week, the participants will perform a postprandial glucose test (OGTT, 75 g
glucose in 100 ml water) at Oslo Metropolitan University. Blood samples will be taken before
and at different time points after the glucose test. One week prior to the intervention week
and during "wash-out" (11 days), the participants will consume the control products which are
high in saturated fat.
At the screening visit (visit 0) the participants will be asked to limit the intake of
dietary fat and fiber from oat and barley one week prior to visit 1 and during the study.
Otherwise, participants will be asked not to change their diet and exercise habits during the
study period. Individuals fulfilling the inclusion criteria will also be invited to
participate in a cross-sectional study for investigating the gut microbiota in a healthy
population.
An OGTT will be performed at visit 1, 2, 3 and 4.
The participants will receive test meals after screening and before visit 1, 2, and 3.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04991792 -
Effect of an Infant Formula With Synbiotics in Infants Born Via Caesarean Section
|
N/A | |
| Completed |
NCT02151825 -
Effect of a Synbiotic on the Gut Microbiota and Adiposity-related Markers in Healthy Overweight Subjects
|
N/A | |
| Completed |
NCT01545219 -
A Study of a Prebiotic, a Probiotic and a Synbiotic Upon the Gut Microbiota and Immune Response of Healthy Volunteers
|
N/A | |
| Active, not recruiting |
NCT04435548 -
Westlake Gut Microbiome Study
|
||
| Enrolling by invitation |
NCT05057039 -
The Study of Gut Microbiota in Hypertensive Patients
|
||
| Not yet recruiting |
NCT05039060 -
Modified MAC Diet and Gut Microbiota in CRC Patients
|
N/A | |
| Completed |
NCT03746158 -
Interindividual Variation in Excretion of Curcumin
|
N/A | |
| Active, not recruiting |
NCT03266055 -
Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
|
N/A | |
| Completed |
NCT04960878 -
The Effect of Synbiotics on the Upper Respiratory Tract Infection
|
N/A | |
| Active, not recruiting |
NCT05607745 -
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
|
N/A | |
| Recruiting |
NCT04120051 -
The SIMBA Project - The Effect of a Prebiotic Supplement on Glucose Metabolism and Gut Microbiota in Obese Adults
|
N/A | |
| Not yet recruiting |
NCT05481866 -
Targeting Gut Microbiota and Metabolites for Very Preterm Infants Through Oropharyngeal Administration of Colostrum
|
N/A | |
| Completed |
NCT03293693 -
Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects
|
N/A | |
| Completed |
NCT02207140 -
Effect of Multi-species Probiotic HOWARU® Restore, on Gut Microbiota of Elderly
|
Phase 0 | |
| Recruiting |
NCT04203459 -
The Mechanism of Enhancing the Anti-tumor Effects of CAR-T on PC by Gut Microbiota Regulation
|
||
| Active, not recruiting |
NCT03259685 -
Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
|
N/A | |
| Recruiting |
NCT06157346 -
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
|
||
| Completed |
NCT03203044 -
Impact of Soylent Consumption on Human Microbiome Composition
|
N/A | |
| Recruiting |
NCT05975541 -
Susceptibility to Infectious Diseases in Obesity
|
||
| Active, not recruiting |
NCT05457439 -
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
|
N/A |