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SARS-CoV-2 Infection clinical trials

View clinical trials related to SARS-CoV-2 Infection.

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NCT ID: NCT06255860 Recruiting - Clinical trials for Sars-CoV-2 Infection

SARS-COV-2 Reinfection and Multisystem Inflammatory Syndrome in Children (MIS-C) Risk: Matched Case-control Study

REPI
Start date: September 22, 2023
Phase:
Study type: Observational

This study is a multicenter, international, non interventional, retrospective study about SARS-CoV-2 and Multisystem Inflammatory Syndrome (MIS-C) reinfection risk in children.

NCT ID: NCT06191393 Recruiting - Clinical trials for SARS-CoV-2 Infection

SARS-CoV-2 and Influenza A/B in Point-of-Care and Non-Laboratory Settings

Start date: November 20, 2023
Phase: N/A
Study type: Interventional

The Metrix COVID/Flu Test will be evaluated for use in Point-of-Care and Non-Laboratory settings in a home testing environment utilizing the clinical study design described herein. The study will take place in simulated home environments which will be set up within or near active clinical settings (e.g., urgent care facilities). This will be a prospective study conducted at three or more investigational sites located within the United States for the clinical validation of the Metrix COVID/Flu Test for the differential detection of SARS-CoV-2, Influenza A, and Influenza B in AN swab or saliva samples. Additional sites may be added to the study in order to meet minimum subject/sample enrollment requirements and geographic prevalence of respiratory virus infections. One or more investigational sites outside of the US (at which participants are required to be fluent in English) may also be included in the study depending on enrollment needs and geographical/seasonal prevalence of respiratory virus infections. Comparator testing will be performed to determine the infection status of each sample for comparison to results generated by the candidate test. The primary comparator for the study will be an FDA-cleared assay for the detection of SARS-CoV-2, Flu A, and/or Flu B.

NCT ID: NCT06168019 Recruiting - COVID-19 Clinical Trials

Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India

ICOPE
Start date: December 26, 2023
Phase:
Study type: Observational

This study will be conducted as a prospective cohort study, enrolling all eligible women in their first trimester of pregnancy during a baseline visit during week 6-13 of pregnancy at Government Medical College Hospital, Nagpur. The Hospital provides primary, secondary, and tertiary care and the obstetric department delivers about 10,000 babies a year. The hypothesis is that co-infection of other respiratory viruses (ORV), particularly COVID-19 and Influenza increases the risk of adverse pregnancy outcomes in mothers and babies and could address the current standard of care in India to not vaccinate pregnant women during pregnancy, by either encouraging vaccination against both viruses before planning a pregnancy or during pregnancy based on global data supporting the safety of this strategy.

NCT ID: NCT06113744 Recruiting - Clinical trials for SARS-CoV-2 Infection

A Phase 1 Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine

Start date: March 10, 2023
Phase: Phase 1
Study type: Interventional

A randomised, blinded, parallel-controlled phase 1 clinical trial to evaluate the safety and preliminary immunogenicity of a COVID-19 mRNA vaccine in a healthy population aged 18 years and older, and to investigate immunisation doses.

NCT ID: NCT06113731 Recruiting - Clinical trials for SARS-CoV-2 Infection

A Phaseâ…¡ Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine

Start date: July 10, 2023
Phase: Phase 2
Study type: Interventional

To evaluate the immunogenicity and safety of a COVID-19 mRNA vaccine (ZSVG-02-O) in a healthy population aged 18 years and older.

NCT ID: NCT06026514 Recruiting - Clinical trials for SARS-CoV-2 Infection

Phase I Safety Study of B/HPIV3/S-6P Vaccine Via Nasal Spray in Adults

Start date: September 18, 2023
Phase: Phase 1
Study type: Interventional

This Phase 1 clinical trial will evaluate the safety and immunogenicity of an intranasal vaccine candidate, a recombinant, live-attenuated, bovine/human parainfluenza virus vector vaccine expressing the 6-P prefusion-stabilized version of the SARS-CoV-2 spike protein.

NCT ID: NCT05897541 Recruiting - Clinical trials for SARS-CoV-2 Infection

Phase 3 Study of S-217622 in Prevention of Symptomatic SARS-CoV-2 Infection

SCORPIO-PEP
Start date: June 9, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this study is to measure the proportion of participants who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (positive reverse transcription polymerase chain reaction [RT-PCR] test) and have coronavirus disease 2019 (COVID-19) symptom(s) with S-217622 tablets compared with placebo tablets in participants who are household contacts of an individual with symptomatic COVID-19.

NCT ID: NCT05892549 Recruiting - COVID-19 Clinical Trials

COVID-19: Early Detection of Worsening by Voice and Respiratory Pattern Characteristics

COVOICE
Start date: June 12, 2023
Phase:
Study type: Observational

In some clinical forms of COVID-19, an uncontrolled hyper-inflammatory reaction known as a "cytokine storm" appears abruptly, around day 7, and is associated with rapid respiratory deterioration, requiring hospitalization in an intensive care unit (ICU). At present, although risk factors for this severe form have been described, there are no validated criteria for determining which individual patients will develop this aggravation. The study of respiratory sounds (amplitude, frequency, ...) has made it possible in other respiratory pathologies (e.g., chronic obstructive pulmonary disease) to predict exacerbations several days in advance. Having a predictive respiratory pattern for worsening in COVID-19 would make it possible to anticipate the need for intensive care hospital beds, by means of a tool easily available on a mobile phone.

NCT ID: NCT05855434 Recruiting - Clinical trials for SARS-CoV-2 Infection

The ACDC Study Assessing Cognitive Deterioration in COVID-19

ACDC
Start date: February 1, 2023
Phase:
Study type: Observational

The long-term impact and effects of COVID-19 are still being determined. However, what is clear, is that some people are still struggling following a period of illness with COVID-19. Now known as 'long covid' or 'post covid-19 syndrome', people are not only experiencing physical symptoms like fatigue and breathlessness, but also psychological difficulties, as well as cognitive changes often referred to as 'brain fog'. This can include symptoms, such as changes in memory, difficulties with organisation and problem solving, as well as the ability to concentrate. Evidence from other research areas suggest that these changes could be due to shrinkage in areas of the brain that control functions like memory and concentration. There are also connections between different brain areas that work together to perform tasks such as remembering and concentrating, and these areas may also be affected by COVID-19. The purpose of this study is to scan the brains of patients reporting cognitive changes having been hospitalised with COVID-19 infection to see if any of these areas or connections have changed after infection and whether this might explain these cognitive changes.

NCT ID: NCT05713305 Recruiting - Anxiety Clinical Trials

Effect of an Online Self-help Psychological Intervention on Non-ICU Specialty Care During the COVID-19 Outbreak

Start date: January 18, 2023
Phase: N/A
Study type: Interventional

Timely interventions may reduce the occurrence of post-traumatic stress disorder (PTSD) in ICU medical staff. Existing research suggests that either self-learning psychological relief methods or seeking online counseling or therapy from professional psychotherapists during the SARS-CoV-2 Omicron outbreak has the potential to alleviate the emotional distress and promote the physical and mental health of health care workers. Web-based online mental health interventions complemented by joint effective mental health advice can further reduce harmful negative effects.