Clinical Trials Logo

Clinical Trial Summary

Ageing is characterised by a change in body composition with a parallel decrease in muscle mass and an increase and central redistribution of fat. When drastically exacerbated, these two processes culminate in a condition known as sarcopenic obesity (SO). SO is characterised by the coexistence of obesity and sarcopenia (i.e. reduced muscle mass and function) and is a growing public health problem in the elderly. The health risks of obesity and sarcopenia act synergistically, maximising the risk of disability of OS. The molecular mechanisms underlying OS are largely unknown. Increased fat mass induces chronic systemic inflammation and alters the profiles of adipokines and hormones, promoting the development of sarcopenia. On the other hand, the reduction in muscle tissue (SM) typical of sarcopenia is characterised by an alteration in the metabolic properties of skeletal muscle with an increase in insulin resistance and a reduction in energy expenditure that favours the accumulation and dysfunction of adipose tissue (AT). The cellular alterations that would seem to underlie OS are: altered autophagy, cellular senescence, epigenetic and mitochondrial alterations and maladaptive activation of intra- and intercellular inflammatory circuits (e.g. cytokines, extracellular vesicles, dysfunctional circulating leukocytes). However, the interconnections between these mechanisms are still unclear. The impact of OS can be dramatic on the health and quality of life of those affected. Therefore, the identification of early biomarkers that can recognise overweight and obese individuals at risk of developing SO is of paramount importance. This would shed light on the heterogeneity of an otherwise homogeneous clinical condition, opening new horizons towards the conscious design of more personalised therapeutic strategies, allowing a more rational use of the limited resources available for the growing elderly population. The study design designed to achieve this aim is a cross-sectional observational study with an additional multicentre procedure lasting two years.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06320158
Study type Observational
Source IRCCS San Raffaele
Contact Patrizia Rovere Querini, PhD, MD
Phone +390226436095
Email rovere.patrizia@hsr.it
Status Recruiting
Phase
Start date May 22, 2023
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Completed NCT03119610 - The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Phase 1/Phase 2
Recruiting NCT03212391 - WAVE Study- Walking and Aging in VErona Study N/A
Recruiting NCT05289219 - Effects of Physical Exercise on Sarcopenia After Bariatric Surgery N/A
Completed NCT05143398 - Nutritional Supplementation in Sarcopenic Obesity N/A
Completed NCT04122638 - Prevalence of Sarcopenia and Sarcopenic Obesity in Older Adults
Recruiting NCT05582668 - Sarcopenia After Bariatric Surgery in Older Patients: A Cohort Study
Active, not recruiting NCT02379026 - Lifestyle Modifications for the Treatment of Sarcopenic Obesity N/A
Enrolling by invitation NCT05638035 - Effects of Obesity on Rectus Femoris Muscle Thickness, Sarcopenia, Gait and Balance in Women
Recruiting NCT05477277 - Adverse Outcomes and Mortality in Liver Transplant N/A
Not yet recruiting NCT04597788 - Efficacy of Protein Supplemented Very Low Calorie Meals on Weight Loss N/A
Completed NCT04771377 - Effect of Protein Supplementation and a Structured Exercise Program on Muscle in Women After Bariatric Surgery. N/A
Recruiting NCT03347773 - Oral Nutritional Supplement Intervention Among Hemodialysis Patients With Sarcopenic Obesity N/A
Active, not recruiting NCT04272073 - A High-PRotein Mediterranean Diet and Resistance Exercise for Cardiac Rehabilitation N/A
Completed NCT03863379 - Sarcopenic Obesity in Neurodisabilities
Recruiting NCT04221750 - Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors Phase 3
Completed NCT05918159 - Effects of Sarcopenia on General Health Status in Elderly: a Population-based Study
Completed NCT05029713 - Sarcopenic Obesity in Liver Transplanted Patients
Completed NCT03370211 - Resistance Training and Sarcopenic Obesity Elderly Women N/A
Recruiting NCT05734755 - Dietary Programme and Exercise Training in Combination or Separately on Managing Sarcopenic Obesity in Older Adults N/A
Completed NCT05938205 - Multicomponent Analysis of phYsical Frailty BiomarkErs: Focus on Mitochondrial Health - MAYBE N/A