Sarcoma Clinical Trial
Official title:
Comprehensive Genome Sequencing of Desmoplastic Small Round Cell Tumors
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research study is studying genes in samples from younger patients with
desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.
OBJECTIVES:
- To perform whole-exome sequencing on desmoplastic small round cell tumor (DSRCT)
samples and their available matched normal samples to identify novel mutations, single
nucleotide polymorphisms, or copy number changes associated with these tumors.
- To identify regions of interest that may be involved in the pathogenesis (including the
region of EWSR1-WT1 translocation) from the whole-exome sequencing and perform detailed
resequencing and transcriptone sequencing to further define the molecular aberrations
at the RNA level.
OUTLINE: This is a multicenter study.
Archived tumor tissue samples are analyzed for DNA sequencing, effects of RNA on gene
expression levels, novel RNA isoforms, splice variants, and translocations.
;
Observational Model: Case Control, Time Perspective: Retrospective
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