Clinical Trials Logo

Clinical Trial Summary

The perception of astringency is thought to involve the interaction between tannins and salivary proteins. However, the mechanisms underlying this interaction are poorly understood. The tannins' subclass known as type A proanthocyanidins seems to have a positive effect on human health. Despite that, humans show large individual differences in the sensory perception and acceptance of astringent foods such as tea, wine and chocolate suggesting that this variation may have a genetic basis. Salivary proteins play an essential role both in affecting oral taste perception and in maintaining a healthy oral environment. Diverse microorganisms inhabit the oral cavity. The interactions between oral microbiota, host and environmental factors influence microbial homeostasis and ultimately human oral health. Understanding individual differences in salivary proteins, oral microbiome and the mechanisms by which tannins evoke the perception of astringency could provide important insights into the role of these compounds in human nutrition and health.


Clinical Trial Description

This study examines the effects of a daily Cranberry Polyphenol Extract (CPE) oral rinse on salivary protein responses and the oral microbiome (as a proxy measure of oral health). The study will be conducted in healthy adults who are presumably at high-risk or low-risk of oral disease. High risk individuals include non-tasters of PROP (6-n-propylthiouracil) and homozygous recessive for TAS2R38 (Taste 2 Receptor Member 38) gene, while low-risk individuals include super-tasters of PROP and homozygous dominant for TAS2R38 gene. The specific aims are to determine if the use of cranberry polyphenol extract rinse will: 1. alter the oral microbial profile 2. induce changes in the salivary protein response 3. be associated with changes in taste and flavor perception Participants will be screened for good overall and oral health. Each subject's period of participation will be 2 weeks. Days 1-3 of the study is a run-in period. Subjects will rinse with spring water 2-times/day (after brushing their teeth in the morning and evening). During days 4-14, subjects will rinse in a similar manner with a solution of CPE in spring water. Saliva will be collected from subjects in a brief session (10 min) on day 1, day 3, and day 14. Saliva samples will be analyzed for gene, salivary proteins and microbial profile analysis. The purpose of this analysis is to measure the relative ratios of beneficial vs. disease-causing microbes in the mouth using microbial whole-genome sequencing (WGS). On each of the testing days, subjects will also evaluate food samples for standard taste and flavor attributes. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05819073
Study type Interventional
Source Rutgers, The State University of New Jersey
Contact
Status Completed
Phase N/A
Start date November 1, 2022
Completion date November 14, 2023

See also
  Status Clinical Trial Phase
Completed NCT05447104 - Salivary Flow Promoted by Sugar-Free Chewing Gum N/A
Completed NCT02052973 - Efficacy of Propolis Varnish Against Oral Biofilm Phase 1/Phase 2
Not yet recruiting NCT03877705 - Xylitol Chewable Tablets Versus Xylitol Chewing Gum in Geriatric Bedridden Patients Early Phase 1
Completed NCT03526770 - Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink N/A
Completed NCT06343337 - The Effects of Pregnancy on Oral Health N/A
Completed NCT03513575 - Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Flavoured Milk N/A
Active, not recruiting NCT03529604 - Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
Completed NCT04107688 - Taste Perception, Salivary Proteins & the Oral Microbiome N/A
Completed NCT03501238 - Interaction of Salivary Proteins and Polyphenols N/A
Completed NCT05394090 - The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke N/A
Active, not recruiting NCT02881827 - Saliva Analysis After Low-level Laser Therapy Application on the Masseter Muscle Located Above Parotid Salivary Gland N/A
Completed NCT01578603 - Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Phase 4
Completed NCT05245019 - Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity N/A
Completed NCT03510962 - Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Fruit Juice N/A
Active, not recruiting NCT03418909 - Functional Outcome After Treatment for Oropharyngeal Squamous Cell Carcinoma