Pharmacokinetics After Oral Intake Clinical Trial
Official title:
Examination of the Bioavailability and Bioactivity of the Two Natural Food Ingredients 6-Prenylnaringenin and 8-Prenylnaringenin.
The prenylflavonoids 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN) are secondary plant substances, almost exclusively found in hops (Humulus lupulus). Both compounds have known potential biological properties, but poor bioavailability due to their low oral absorption and retention. Our study followed a single dose (500 mg 6- or 8-PN), placebo controlled, randomized, double-blind, three armed crossover study design with ≥2-week washout periods. Plasma, PBMC and urine samples were collected at intervals up to 24 h after intake. Investigators investigated the safety, pharmacokinetics and impact of oral prenylflavonoids on the function of cells of the immune system.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02944097 -
Bioavailability of Resveratrol From Vineatrol30 Extract Incorporated Into Micelles
|
Early Phase 1 | |
| Completed |
NCT03530436 -
Comparison of Curcumin Bioavailability
|
N/A | |
| Completed |
NCT02944084 -
Absorption and Excretion Kinetics of the Bioactive Ingredients of Rice Bran Extract
|
Early Phase 1 |