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Rupture clinical trials

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NCT ID: NCT03294759 Active, not recruiting - Clinical trials for ACL - Anterior Cruciate Ligament Rupture

Bio ACL Reconstruction Amnion Collagen Matrix Wrap and Stem Cells

BioACLRCT
Start date: September 6, 2017
Phase: N/A
Study type: Interventional

Collagen based -membrane derived from amniotic tissue can be used to help reestablish the natural synovial lining of the reconstructed ACL, in effect acting as both a barrier from the synovial fluid and as a scaffold to contain autologous mesenchymal stem cells and growth factors contiguous with the graft, thus aiding and perhaps accelerating the natural maturation and ligamentization process of the implanted graft tissue. Acceleration and improvement in graft maturation and strength would be a significant advancement in sports medicine allowing safer and earlier return to sports and activity

NCT ID: NCT03113734 Active, not recruiting - Orthopedic Clinical Trials

Clinical Screening of Acute Ruptures of the Anterior Cruciate Ligament of the Knee

ACL-TS
Start date: April 29, 2017
Phase:
Study type: Observational

This study develops the construction and validation of a reliable functional screening score in LCA ruptures in the immediate post-traumatic period. This score, realizable in an emergency, would be an early warning signal requiring an emergency consultation with an orthopedic surgeon. It would be a tool for screening acute LCA ruptures at a time when ligament testing maneuvers are too painful to be contributory to the diagnosis. It would avoid a premature return to dangerous activity for the knee with a rupture of the LCA. The other impact would be economical since it would avoid the realization of unnecessary MRI. On the other hand, it will allow patients with LCA rupture to have faster access to MRI. The hypothesis of the study is that a validated functional score would make it possible to sort the patients in the emergencies and to prescribe the MRI only in the cases of effective rupture of the LCA.

NCT ID: NCT02996253 Active, not recruiting - Clinical trials for Achilles Tendon Rupture

Endoscopic Transfer of Flexor Hallucis Longus Tendon for Chronic Achilles Tendon Rupture

Start date: December 2015
Phase:
Study type: Observational

The transfer of Flexor Hallucis Longus (FHL) in the management of chronic Achilles tendon ruptures has demonstrated good functional outcome, but an extensive surgical field at a vulnerable location may lead to increased risk for soft tissue problems. The arthroscopic FHL transfer may reduce the risk for soft tissue problems. Functional outcome parameters are investigated, wound/soft tissue complications registered.

NCT ID: NCT02875210 Active, not recruiting - Clinical trials for Anterior Cruciate Ligament Rupture

Comparative Study of Anterior Tibial Translation Measurement by Four Laximeters in Anterior Cruciate Ligament Ruptures

LAXIMETRIE
Start date: July 2015
Phase: N/A
Study type: Interventional

Actually, there are several laximeters for measuring anterior tibial translational in case of anterior cruciate ligament rupture. The most commonly used are telos, KT-1000, GnrB and Rolimeter. Results of these instrumented tests, which expressed in differential (millimeters values), have a bad correlation between them and so are not comparable in current literature. The aim of this study was to compare results of these tests and establish a ratio (pathologic knee laxity/ healthy knee laxity) to reduce differences between each instrumented test.

NCT ID: NCT02816606 Active, not recruiting - Clinical trials for Anterior Cruciate Ligament Rupture

Anterior Cruciate Ligament Radiology Follow-up Study

Start date: June 2016
Phase:
Study type: Observational

Following recent advances in the understanding of successful anterior cruciate ligament (ACL) reconstruction, three important factors have been identified: femoral tunnel positioning, femoral tunnel aperture shape, and native remnant preservation. Accordingly, the researchers have adapted their technique to address these goals. This study is designed to assess the feasibility of evaluating these graft characteristics, on post-operative imaging, and the ability to show potential improvements with the researchers' technical changes. The study plans to use three-dimensional computer tomography (3D-CT) and magnetic resonance imaging (MRI) to assess these properties and the integration of the graft. In addition, the researchers will use their routine functional scores to monitor the patients' outcome. If successful, the research team hope to set-up a randomised control trial of this alternative technique versus conventional methods with assessment through the same imaging mediums and clinical follow-up.

NCT ID: NCT02680821 Active, not recruiting - Clinical trials for Rupture of Anterior Cruciate Ligament

Reconstruction of the Anterolateral Ligament (ALL) With Revision Anterior Cruciate Ligament (ACL) Surgery

Start date: February 2016
Phase: N/A
Study type: Interventional

Patients with combined Anterolateral ligament (ALL) reconstruction- Anterior cruciate ligament (ACL) revision will have a better rotational knee stability and therefore better patient reported outcome measure (PROM) scores compared to patients, who have ACL revision surgery without ALL reconstruction.

NCT ID: NCT02374775 Active, not recruiting - Clinical trials for Myocardial Infarction

Exploring the MEchanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and computationaL Fluid Dynamic

EMERALD
Start date: September 2014
Phase: N/A
Study type: Observational

The EMERALD trial is a multinational, multicenter study. The patients presented with AMI/definite evidence of plaque rupture and had underwent coronary CT angiography from 1 month to 2 year prior to the event will be retrospectively searched. Plaques in the non-culprit vessels will be regarded as internal control to the ruptured plaque in the culprit vessel.

NCT ID: NCT02318472 Active, not recruiting - Clinical trials for Deep Venous Thrombosis

Early Mobilization After Achilles Tendon Rupture

EarlyM-Achil
Start date: November 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether early mobilization after Achilles tendon rupture can speed up healing, prevent development of venous thromboembolism and improve patient outcome.

NCT ID: NCT02310854 Active, not recruiting - Clinical trials for Anterior Cruciate Ligament Injury

Acute Anterior Cruciate Ligament Rupture; RecOnsTruction Or Repair?

ROTOR
Start date: November 2014
Phase: N/A
Study type: Interventional

To investigate the hypothesis that suture repair of a ruptured vkb, combined with a dynamic intraligamentary stabilization and microfracture of the femoral notch, results in at least equal effectiveness compared with an ACL reconstruction using autologous hamstring in terms of functional recovery one year postoperatively in terms of a patient self-reported outcome related to be able to conduct daily and sporting activities. Secondary, the evaluation of clinical outcomes, self-reported by the patient outcomes, osteoarthritis, rehabilitation time required for return to daily and sporting activities and levels of sporting activity which has returned in patients with status after an ACL rupture and suture repair augmented with a dynamic intraligamentary microfracture and stabilization of the femoral notch in comparison with an anterior cruciate ligament reconstruction with the ipsilateral hamstring graft.

NCT ID: NCT01845662 Active, not recruiting - Clinical trials for Non Traumatic Splenic Rupture

Non-traumatic Rupture of the Spleen. Can Splenectomy be Applied Selectively?

Start date: April 2013
Phase: N/A
Study type: Observational

Purpose: Non-traumatic rupture of the spleen should be suspected when patients (especially young men) present with abdominal pain and a history of acute infectious or myeloproliferative disorders. Preoperative imaging studies in hemodynamically stable patients may obviate the need for surgery even in the presence of massive hemoperitoneum. The purpose of this research is to inform acute management where spontaneous rupture is suspected in order to avoid surgery where appropriate, rationalise angiographic intervention and blood transfusion. Hypothesis: Indentifying the cause of injuries can help target preventative intervention. Background: Non-traumatic rupture of the spleen is a rare condition. It may occur in the diseased spleen secondary to a variety of pathologies including malaria and myeloproliferative disorders. In some cases rupture may occur in an apparently normal spleen. The incidence, symptoms, causes, therapy and prognosis are poorly defined. The investigators, therefore, propose an extension of retrospective analysis conducted, presented and published in 2003 to examine all the cases of non-traumatic splenic rupture treated at Ziv Medical Centre from the last 26 years to present. Methods: Analysis of the medical notes of all patients with spontaneous splenic rupture in the medical archives. The investigators hope to determine the true incidence of this condition within the local population, increasingly diverse in origin, travel and the incidence of predisposing infectious disease; and to devise a practical protocol in their safe diagnosis and management, especially as non-operative interventions have grown in safety and effectiveness. Discussion: Although rare, spontaneous splenic rupture may be fatal if not suspected or treated inappropriately. Understanding the pitfalls in diagnosis and management better informs decision making towards improved care of these patients.