Rosacea Clinical Trial
Official title:
Characterization of the Facial and Gut Microbiome in Identical and Fraternal Twins With Rosacea; Comparison to Healthy Controls
Questionnaires will be completed by each member of the twin set. A board-certified dermatologist will examine each member to categorize the type and severity of their rosacea. The facial and gut microbiome will be sampled and sent for microbial analysis.
1. Twin set subjects will be administered a questionnaire regarding demographics (age,
gender, state of residence, time lived together, birth order), rosacea duration, prior
rosacea treatment, diet (and similarity of diet to twin), co-morbidities, signs and
symptoms suggestive of cardiovascular or gastrointestinal disease/disorder.
2. Subjects will be examined by a board-certified dermatologist and global assessment,
inflammatory counts and clinician's erythema score will be performed. Eyes will be
examined for signs of ocular rosacea.
3. Facial microbiome sampling will be performed on-site utilizing a kit manufactured by
UBiome. The skin with active rosacea will be swabbed and the swab immediately placed in
sample medium. The tube is then shipped to the manufacturer for 16s rRNA shotgun
metagenomics to identify resident bacterial genera and species. (16) This can be
compared to their extensive library of normal controls, to the other member of the twin
set and to acne subjects.
4. Subjects will be given a fecal microbiome kit for home sampling. Feces obtained from
toilet paper is collected and placed in the sample medium. Subjects can either ship
directly or return to the study site for shipping.
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