A Study of Ciclesonide Nasal Spray in Patients 18 Years and Older With Seasonal Allergic Rhinitis (BY9010/M1-413)

Rhinitis, Allergic, Seasonal Clinical Trial

Official title:

A Randomized, Double-blind, Placebo-controlled, Parallel-group Study Using the Environmental Exposure Chamber (EEC) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray (200 mcg, Once Daily), in the Treatment of Seasonal Allergic Rhinitis (SAR) in Patients 18 Years and Older

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00384475
• Other study ID #: BY9010/M1-413
• Status: Completed
• Phase: Phase 3
• First received: October 5, 2006
• Last updated: November 29, 2016
• Start date: October 2006
• Est. completion date: January 2007

Study information

• Verified date: October 2016
• Source: AstraZeneca
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Health Canada
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the safety and effectiveness of ciclesonide nasal spray as compared with placebo (inactive substance) nasal spray in relieving symptoms of seasonal allergic rhinitis caused by pollen. Ciclesonide will be administered once during the exposure to ragweed pollen in a controlled environment. The study duration consists of a baseline period (up to 5 days) and a treatment period (1 day). The study will provide further data on safety and tolerability of ciclesonide.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 500
• Est. completion date: January 2007
• Est. primary completion date: January 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Main Inclusion Criteria:

• Written informed consent

• General good health

• History of SAR to short ragweed pollen for 2 years immediately preceding the study

• Demonstrated sensitivity to short ragweed known to induce SAR through a standard skin prick test

Main Exclusion Criteria:

• Clinically significant physical finding of nasal anatomical deformities causing greater than 50% obstruction, including but not limited to nasal polyps, septal defects, respiratory tract malformations, nasal trauma or surgery

• Known hypersensitivity to any corticosteroid

• History of a respiratory infection or disorder including but not limited to bronchitis, pneumonia, chronic sinusitis, influenza or SARS (severe acute respiratory syndrome) within 14 days preceding the Screening Visit

• History of alcohol or drug abuse within 2 years preceding the Screening Visit

• Active asthma requiring treatment of inhaled or systemic corticosteroids and/or routine use of beta-agonists or any controller drugs

• Use of antibiotic therapy for acute conditions within 14 days preceding the Screening Visit

• Exposure to systemic corticosteroids for any indication, chronic or intermittent within 60 days preceding the Screening Visit

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Hay Fever
• Rhinitis
• Rhinitis, Allergic
• Rhinitis, Allergic, Seasonal

Intervention

Drug:
• Ciclesonide Nasal Spray

Locations

Country	Name	City	State
Canada	Altana Pharma/Nycomed	Ontario, Mississauga

Sponsors (1)

Lead Sponsor	Collaborator
AstraZeneca

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Onset of action, measured by change from baseline in Total Nasal Symptom Score.
Secondary	changes in symptoms, safety.

External Links

•   BY9010-M1-413-RDS-2007-06-05.pdf