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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02738281
Other study ID # RDCRN 5211
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 2015
Est. completion date July 31, 2021

Study information

Verified date August 2021
Source University of Alabama at Birmingham
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to advance understanding of the natural history of Rett syndrome (RTT), MECP2-duplication disorder (MECP2 Dup), CDKL5, FOXG1, and individuals with MECP2 mutations who do not have RTT including the range of clinical involvement and to correlate genotype-phenotype over a broad spectrum of phenotypes. While much has been learned about RTT, improvements are required in understanding the role of factors such as X chromosome inactivation, genetic background, and others including the environment, on the great variability observed even between individuals with the same MECP2 mutation. These data will be essential to the development and conduct of clinical trials that are anticipated from ongoing studies in animal models for RTT. This study will not include clinical trials, but should set the stage for such trials and other translational research projects (e.g., development of biomarkers).


Description:

At the present time, effective treatments for RTT, MECP2 Dup, or Rett-related disorders are lacking. Substantial progress has been made in RTT over the past eleven years such that this study represents a narrowing of focus to mutations or duplications of the MECP2 gene and related disorders, including those with phenotypic overlap. Understanding of RTT has advanced remarkably well through the Rett Syndrome Natural History Clinical Protocol (NHS) and correspondingly advancement in the basic science realm has moved forward with equivalent success. Thus, progress in clinical and basic science has led to the establishment of clinical trials and other translational studies that hold promise for additional clinical trials in future. In the process, however, additional MECP2- and RTT-related disorders that were unknown at the time the original proposal have been identified. In addition, substantial clinical variability in individuals with RTT that cannot be explained by differences in mutations alone must be explored further. In fact, variability among individuals with identical mutations has led to the search for additional explanations. At the time of the initial application (2002), just three years after the identification of the gene, MECP2, as the molecular link to RTT, the variation in clinical disorders related to MECP2 mutations or to the related but quite different MECP2 Dup were unknown. Each disorder is characterized by significant neurodevelopmental features related either to alterations in the MECP2 gene or related to phenotypes closely resembling those seen in individuals with RTT. Further, the phenotypic overlap with RTT due to mutations in CDKL5 and FOXG1 was also unexplored. This new study will build on the substantial progress made in understanding both classic and variant RTT and to add these related disorders, MECP2 Dup and the Rett-related disorders including CDKL5, FOXG1, and individuals with MECP2 mutations who do not have RTT. A comprehensive clinical research program will be performed including clinical, neurophysiologic, and molecular and biochemical markers across these different, but related disorders. This protocol will address the natural history components only and will serve as the basis for other study protocols including the neurophysiologic and biomarker studies. Thereby, these studies will represent a continuing pathway to focus and inform not only the ongoing but also the emerging clinical trials.


Recruitment information / eligibility

Status Completed
Enrollment 1044
Est. completion date July 31, 2021
Est. primary completion date July 31, 2021
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Individuals of both genders and of all ages, with RTT, MECP2 Dup, and, RTT-related disorders including those with mutations or deletions in CDKL5 and FOXG1 genes, or those with RTT (atypical or typical) who are mutation negative. Exclusion Criteria: - Individuals who do not meet the above criteria will be excluded.

Study Design


Locations

Country Name City State
United States University of Alabama at Birmingham Birmingham Alabama
United States Children's Hospital Boston Boston Massachusetts
United States Rush University Medical Center Chicago Illinois
United States Cincinnati Children's Hospital Medical Center Cincinnati Ohio
United States Cleveland Clinic Cleveland Ohio
United States University of Colorado Denver Denver Colorado
United States Greenwood Genetic Center Greenwood South Carolina
United States Baylor College of Medicine Houston Texas
United States Vanderbilt University Nashville Tennessee
United States UCSF Oakland Benioff Children's Hospital Oakland California
United States Children's Hospital of Philadelphia Philadelphia Pennsylvania
United States Washington University School of Medicine and St. Louis Children's Hospital Saint Louis Missouri
United States Gillette Children's Specialty Healthcare Saint Paul Minnesota
United States University of California San Diego San Diego California

Sponsors (6)

Lead Sponsor Collaborator
University of Alabama at Birmingham Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Center for Advancing Translational Science (NCATS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Rare Diseases Clinical Research Network

Country where clinical trial is conducted

United States, 

References & Publications (73)

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* Note: There are 73 references in allClick here to view all references

Outcome

Type Measure Description Time frame Safety issue
Primary Clinical longitudinal assessments in Rett syndrome (RTT) as measured by mean growth over 5 years. subject's height will be measured in inches at baseline and at 5 years. The change will be calculated and then the mean change will be reported. at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as measured by mean change in head circumference over 5 years the mean change in head circumference (measured in Centimeters) will be reported at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as measured by mean number of stereotypic movements at 5 years The mean number of stereotypic movements in a 24 hour period at 5 years. at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as the percent of subjects with reported epilepsy at 5 years The Percent of subjects reporting epilepsy by 5 years 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as the percent of subjects with reported scoliosis at 5 years Percent of subjects with reported scoliosis at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as the percent of subjects with MECP2 mutations at 5 years % of subjects with MECP2 mutations to 5 years at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as reported by the mean Clinical Severity Scale (CSS) at 5 years The CSS is the clinical severity scale. at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in Rett syndrome (RTT) as measured by the mean Motor Behavioral Assessment (MBA) at 5 years the MBA is the motor behavioral (performance) score at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: mean growth rate over 5 years with subjects having MECP2 duplication syndrome subject's height will be measured in inches at baseline and at 5 years. The change will be calculated and then the mean change will be reported. at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: mean change in head circumference 5 years with subjects having MECP2 duplication syndrome the mean change in head circumference (measured in Centimeters) will be reported at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: mean number of stereotypic movements in a 24 hour period at 5 years with subjects having MECP2 duplication syndrome The mean number of stereotypic movements in a 24 hour period at 5 years. at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: percent of subjects reporting scoliosis 5 years with subjects having MECP2 duplication syndrome Percent of subjects with reported scoliosis at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: percent of subjects surviving at 5 years with subjects having MECP2 duplication syndrome Percent of subjects surviving at 5 years after start of study at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: the mean CSS score at 5 years with subjects having MECP2 duplication syndrome the CSS........ at 5 years after enrollment
Primary Clinical and neurobehavioral longitudinal assessments in MECP2 duplication syndrome: the mean MAB score at 5 years with subjects having MECP2 duplication syndrome the MBA........ at 5 years after enrollment
Secondary Quality of Life Measures in RTT Summative data are provided by the quality of life assessments for children (CHQ), the mean score will.be reported at 5 years post enrollment
Secondary Quality of Life Measures in MECP2 duplication syndrome Summative data are provided by the quality of life assessments for children (CHQ), the mean scores will be reported. at 5 years post enrollment
Secondary Quality of Life Measures in RTT-related disorders. Summative data are provided by the quality of life assessments for children (CHQ), the mean score will be reported. at 5 years post enrollment
Secondary Quality of Life Measures in RTT Summative data are provided by the quality of life assessments from the principal caregiver (SF-36), the mean score will be reported. at 5 years post enrollment
Secondary Quality of Life Measures in MECP2 duplication syndrome Summative data are provided by the quality of life assessments from the principal caregiver (SF-36), the mean score will be reported. at 5 years post enrollment
Secondary Quality of Life Measures in RTT-related disorders Summative data are provided by the quality of life assessments from the principal caregiver (SF-36), the mean score will be reported. at 5 years post enrollment
See also
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