Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma.

Status Completed

Clinical Trial Summary

Bone marrow-derived mesenchymal stem cells (MSC) therapy is a promising treatment for several degenerative diseases, including retinopathies and glaucoma, however no previous safety study involving humans has been conducted. The objective of this study is to evaluate effects of autologous bone marrow-derived MSC transplantation in the worst eye of 10 patients with legal bilateral blindness due to glaucoma. Primary outcome are types and severity of adverse effects. Secondary outcomes are changes in visual field, visual acuity, optical coherence tomography, and retinal ganglion cells function.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02330978
Study type	Interventional
Source	University of Sao Paulo
Contact
Status	Completed
Phase	Phase 1
Start date	January 2014
Completion date	September 2016

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