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Retinal Degeneration clinical trials

View clinical trials related to Retinal Degeneration.

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NCT ID: NCT01399515 Completed - Clinical trials for Retinitis Pigmentosa

Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa

VPA_RP
Start date: March 2011
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of oral valproic acid to slow the progression of visual function and/or to improve the visual function in patients with retinitis pigmentosa (RP). Enrolled subjects in valproic acid group will be treated with oral valproic acid 500mg daily for 48 weeks. Visual function and safety will be assess before and after treatment (48 weeks) between valproic acid and control groups.

NCT ID: NCT01024998 Completed - Clinical trials for Macular Degeneration

Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD)

Start date: January 11, 2010
Phase: Phase 1
Study type: Interventional

This Phase 1 clinical research study will examine the safety and tolerability of an experimental gene transfer agent, AAV2-sFLT01, in patients with Neovascular Age-Related Macular Degeneration (AMD).

NCT ID: NCT01024803 Completed - Clinical trials for Retinitis Pigmentosa

Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients

Start date: December 2009
Phase: N/A
Study type: Interventional

Patients suffering from hereditary retinal degeneration receive a retinal implant to restore sight. Subretinal implant "ON" results in significant visual acuity improvement, when compared to "OFF" condition.

NCT ID: NCT01003691 Completed - Clinical trials for Macular Degeneration

Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

Start date: August 5, 2010
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and tolerability of multiple doses of RN6G in subjects with advanced dry, age-related macular degeneration including geographic atrophy.

NCT ID: NCT00877032 Completed - Clinical trials for Macular Degeneration

Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration

Start date: April 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety and tolerability of RN6G in patients with dry, age-related macular degeneration.

NCT ID: NCT00746668 Completed - Clinical trials for Retinal Degeneration

A Multi-Center Study of Reading Rehabilitation in Macular Disease

Start date: August 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to measure the effectiveness of a newly-designed oculomotor training program for patients with macular disease, including age-related macular degeneration.

NCT ID: NCT00716586 Completed - Clinical trials for Retinal Degenerations

Treatment of Cystoid Macular Edema in Patients With Retinal Degeneration

Start date: October 2005
Phase: Phase 4
Study type: Interventional

A small percentage of patients with retinal degeneration accumulate fluid in the center of their retina. Previous studies using an oral form of treatment has been successful in decreasing this fluid which improves vision. This study will test the use of a topically applied form of this treatment to the eye to reduce the amount of fluid and improve or preserve vision.

NCT ID: NCT00643747 Completed - Clinical trials for Retinal Degeneration

Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis

Start date: January 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of the study is to determine whether gene therapy is safe and effective for the treatment of severe childhood blindness caused by mutations in RPE65.

NCT ID: NCT00403195 Completed - Clinical trials for Diabetic Retinopathy

Clinical and Pathophysiological Description of Ocular Ischemic Syndrome

Start date: November 2006
Phase: N/A
Study type: Observational

The purpose of this study is to characterize the disease Ocular Ischemic Syndrome.

NCT ID: NCT00231010 Completed - Clinical trials for Retinitis Pigmentosa

Molecular Genetics of Retinal Degenerations

Start date: September 26, 2005
Phase:
Study type: Observational

This multinational study will investigate the inheritance of genetic retinal degeneration in families of different nationalities and ethnic backgrounds in order to identify the genes that, when altered, cause retinal degeneration. The retina is a light-sensitive membrane lining the back part of the eye. It relays vision signals to the brain, which the brain interprets into sight. When the retina degenerates, vision is altered and possibly lost. The findings of this study should help improve diagnosis and methods of treatment for these disorders. Participating institutions include: the National Institutes for Health in Bethesda, Maryland; the University of Miami in Florida; the Casey Eye Institute in Portland, Oregon; the Byrd Health Sciences Center in Morgantown, West Virginia; the University of Texas Southwestern Medical School in Dallas, Texas; the University of Tennessee Health Sciences Center in Memphis; the Prasad Eye Institute in Hyderabad, India; National Center of Excellence in Molecular Biology in Lahore, Pakistan; and the Jules Gonin Hospital in Lausanne, Switzerland. Patients with retinitis pigmentosa and closely related diseases such as Usher syndrome, snowflake vitreoretinal dystrophy and Bietti crystalline dystrophy may be eligible for this study. Participants undergo the following tests and procedures: - Medical and surgical history, including family history of vision problems. - Examination to clarify the type of retinal degeneration. - Eye examination, including tests of color vision, field of vision and ability to see in the dark - Electroretinogram to test the function of visual cells. For this test, the patient sits in a dark room for 30 minutes with his or her eyes patched. Then, a small electrode (silver disk) is taped to the forehead and the eye patches are removed. The surface the eyes is numbed with eye drops, and contact lenses are placed on the eyes. The patient looks inside a large dark globe that emits a series of light flashes. Then a light is turned on inside the globe and more lights flash. The contact lenses sense small electrical signals generated by the retina when the light flashes. - Hearing tests for patients with a personal or family history of deafness. Tests include an audiogram, ear examination and test of middle ear function. For middle ear function testing, the patient feels a little air pressure change for a moment and hears some tones. Another test requires the patient to sit quietly with electrodes on the head, forehead and earlobes. - Balance testing, including walking in a straight line, standing with eyes closed in the dark and other tests of coordination, and caloric testing. For the caloric testing, any ear wax in the ear canal is removed before the test begins. Then, electrodes are placed on the skin near the eyes and on the forehead. A small amount of cool (sometimes cold) or warm water is instilled into each ear canal, first one and then the other. - Blood sample collection for genetic testing.