Respiratory Tract Infections Clinical Trial
Official title:
The Usefulness of Point-of-care-testing for C-reactive Protein in Lower Respiratory Tract Infection or Acute Cough
The aim of this study is to evaluate the usefulness in Russian general practice of
C-reactive protein testing in patients with acute cough or lower respiratory tract
infections.
In addition to studying the effect of C-reactive protein testing on the prescription of
antibiotics, the purpose is to find out whether the frequency of referral to radiography
could be reduced.
Eighteen general practitioners, from both urban and rural offices, were randomised into
intervention and control groups. All registrations were made by general practitioners in
their offices.
The case report form was similar to that used in the GRACE study (Genomics to combat
Resistance against Antibiotics in Community-acquired lower respiratory tract infections in
Europe (www.grace-lrti.org) describing symptoms, findings, and treatment in lower
respiratory tract infections.
- The clinical examination included a chest examination and the axillary temperature.
- After the clinical examination, the general practitioners recorded their provisional
diagnosis.
- Chest radiography was accessible for all patients.
The C-reactive protein test was performed in the intervention group at both the first and
second consultations. The Afinion test system was used, which provides results within 5
minutes and before treatment was determined. This test is based on solid-phase sandwich
immunometric analysis.
General practitioners could prescribe any treatment, including antibiotics and other drugs
for the cough and additional medication if deemed necessary.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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