Rapid Detection of Airway Pathogens for Lung Transplantation

Respiratory Tract Infections Clinical Trial

Official title: Rapid Detection of Airway Pathogens for Lung Transplantation

Status Completed

Clinical Trial Summary

Pneumonias and lower respiratory tract infections can have important long-term consequences, particularly in the context of lung transplantation, where pneumonia is a major cause of death. Candidate organs and lung transplant recipients undergo bronchoscopic inspection to assess for lower respiratory tract infection, but traditional culture methods take time, leading to increased risk from inappropriate therapy. The investigators hypothesize that the rapid detection of lower respiratory tract infection, using a semi-quantitative multiplex molecular assay, can decrease the time to appropriate clinical decision making.

Clinical Trial Description

Before and after lung transplantation, clinical decision-making for infection diagnosis can be delayed by the time requirements of traditional culture techniques. This study will enroll lung transplant donor candidates and recipients undergoing assessment for lower respiratory tract infection by bronchoscopic alveolar lavage (or washing). The investigators will record bronchoscopy time and time to test result and clinical management decision based on traditional culture methods. The investigators will perform a semi-quantitative multiplex molecular assay for lower respiratory tract infection using the BioFire Pneumonia Panel and these results will be evaluated by clinicians not directly involved in patient care. Timing and outcome of clinical decision making will be recorded. The investigators will compare the time to result using a paired Student's t-test between traditional and molecular methods. Secondary endpoints include time to clinical decision, postulated changes in clinical decisions, and agreement between methods. ;

Related Conditions & MeSH terms

• Communicable Diseases
• Infection
• Lung Transplantation
• Pulmonary Infection
• Respiratory Tract Infections

• NCT number: NCT03933878
• Study type: Observational
• Source: University of California, San Francisco
• Status: Completed
• Start date: March 19, 2019
• Completion date: March 5, 2021