Respiratory Insufficiency Clinical Trial
Official title:
The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta
The purpose of this study is to determine whether immunonutrition and pre operative nutrition can reduce lenght of respirator support, lenght of stay in the ICU and incidence of post operative infections
Elective surgical repair of a Thoraco (Abdominal) Aneurysm Aorta (T(A)AA) is associated with
high mortality and morbidity. Important complications are renal failure, paraplegia and
respiratory failure.
A retrospective study we performed also revealed high post operative infection rates and
high incidence of respiratory failure.
Improving immune status may reduce the occurrence of infections due to immune chances.
Immunonutrition may enhance the patient’s immune system. Many clinical trials of
immunonutrition in critically ill and surgical patients have been performed. In
meta-analyses it has been shown that immunonutrition results in lower infections rates and
shorter ‘length of stay’ in hospital after major surgery. Immunonutrition has not been
studied yet in TAA(A) surgery. Controversy exists in septic patients.
We designed a prospective randomized placebo controlled trial to study the effect of
immunonutrition on time on ventilatorsupport, lenght of stay in the intensive care unit and
incidence of postoperative infections after TAA(A) surgery. Patients start with oral
supplements besides their normal diet 5 days before surgery. After the operation, the
nutrition is continued by protocol and administered by nasogastric tube until normal entral
feeding is possible. The control group wil receive iso caloric and iso nitrogen nutrition.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05904652 -
High Flow Nasal Oxygen at Extubation for Adults Requiring a Breathing Tube for Treating Severe Breathing Difficulties
|
N/A | |
| Completed |
NCT04030208 -
Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation
|
N/A | |
| Recruiting |
NCT03697785 -
Weaning Algorithm for Mechanical VEntilation
|
N/A | |
| Recruiting |
NCT02989051 -
Fluid Restriction Keeps Children Dry
|
Phase 2/Phase 3 | |
| Completed |
NCT02930525 -
Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation
|
N/A | |
| Recruiting |
NCT02539732 -
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
|
||
| Enrolling by invitation |
NCT02290236 -
Monitored Saturation Post-ICU
|
N/A | |
| Completed |
NCT02056119 -
RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
|
N/A | |
| Terminated |
NCT01583088 -
Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
|
Phase 3 | |
| Withdrawn |
NCT00990119 -
High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)
|
N/A | |
| Completed |
NCT00741949 -
Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF
|
Phase 3 | |
| Completed |
NCT01411722 -
Electrical Activity of the Diaphragm During the Weaning Period
|
Phase 2 | |
| Recruiting |
NCT00187434 -
Comparison of Two Methods of Continuous Positive Airway Pressure (CPAP) to Support Successful Extubation of Infants of Birth Weights ≤ 1500 Grams (C2CPAP)
|
N/A | |
| Completed |
NCT02687802 -
Respiratory Mechanics and Patient-ventilator Asynchrony Index in Patients With Invasive Mechanical Ventilation
|
||
| Not yet recruiting |
NCT05906030 -
Diaphragm Dysfunction and Ultrasound Perioperatively
|
||
| Completed |
NCT03850977 -
Is There an Association Between Chronic Pancreatitis and Pulmonary Function
|
||
| Completed |
NCT02845375 -
Effect of Neuromuscular Blockade and Reversal on Breathing
|
Phase 4 | |
| Recruiting |
NCT03309423 -
Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?
|
N/A | |
| Completed |
NCT04115969 -
Outcome After Non-invasive Ventilation.
|
||
| Not yet recruiting |
NCT03687385 -
The Effect of High-flow Nasal Oxygenation to the Saturation During Analgo-sedation in Different ASA Risk Class Patients
|
N/A |