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Comparison of Gas Exchange Between Two Invasive Mechanical Ventilation Modes in Children — CoCO2  

Respiratory Failure Clinical Trial

Official title:
Comparison of Carbon Dioxide Control During Pressure Controlled (PC) Versus Pressure Regulated Volume Control (PRVC) Ventilation in Children (CoCO2): A Digital, Randomized Controlled Trial

Clinical Trial Summary

This study assesses the feasibility of digital data collection for a randomized controlled trial in a quaternary pediatric intensive care unit and the effect of two commonly used mechanical ventilation modes on gas exchange (CO2) in children over 2 days after randomization. This is a single-center, open-labelled, randomized controlled trial with two parallel 1:1 treatment arms: pressure controlled (PC) vs pressure-regulated volume controlled (PRVC) mechanical ventilation modes. Use to routine digital data is essential to enable health learning systems and to provide rapid clinical trials readiness, as the pandemic has demonstrated. Despite availability of data to perform digital trials in PICU settings, these are yet scarcely done.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05843123
Study type Interventional
Source University Children's Hospital, Zurich
Contact Rebeca Mozun, MD PhD
Phone +41 44 266 39 37
Email rebeca.mozuntorrico@kispi.uzh.ch
Status Recruiting
Phase Phase 4
Start date January 15, 2024
Completion date July 2024
View Details
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