Effect of PEEP on Lung Regional Ventilation and Perfusion

Respiratory Failure Clinical Trial

— PEEP  

Official title:

Effect of Positive End-expiratory Pressure(PEEP) on Regional Ventilation and Perfusion Estimated by Indicator-based Electrical Impedance Tomography(EIT) Method in Critically Ill Patients With Mechanical Ventilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04081155
• Other study ID #: PEEP-lung perfusion
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: June 1, 2020

Study information

• Verified date: January 2019
• Source: Peking Union Medical College Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

Description:

1. When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.

2. Written informed consent was obtained from all patients or next of kin before data were included in the study.

3. Information collected at enrollment included demographic characteristics, such as age, sex.

4. The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.

5. Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: June 1, 2020
• Est. primary completion date: May 28, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. have been placed central venous catheter based on patient's condition

2. Under mechanically ventilation

3. Under sedation and control ventilation mode

4. Year>18

Exclusion Criteria:

1. Pneumothorax

2. pregnancy

3. Severe chest wall wound

4. Severe hypernatremia

Related Conditions & MeSH terms

• Hypoxia
• Mechanical Ventilation Complication
• Respiratory Failure
• Respiratory Insufficiency

Locations

Country	Name	City	State
China	Peking Union Medical College Hospital, Chinese Academy of Medical Science	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Yun Long

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	lung regional ventilation distribution	lung regional ventilation distribution measured by EIT	Hour 1
Primary	lung regional perfusion distribution	lung regional perfusion distribution measured by EIT	Hour 1