Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography

Respiratory Failure Clinical Trial

Official title:

Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02992002
• Other study ID #: EIT Fluid Challenge
• Status: Completed
• Start date: December 2016
• Est. completion date: December 2017

Study information

• Verified date: May 2018
• Source: University of Schleswig-Holstein
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT). EIT data will be collected before, during and after infusion of 500 ml of crystalloid solution in mechanically ventilated patients on an operative intensive care unit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: December 2017
• Est. primary completion date: December 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients on mechanical ventilation

• clincial decision to monitor regional ventilation with electrical impedance tomography

• clinical indication for fluid challenge

• established cardiac output monitoring with transpulmonary thermodilution

Exclusion Criteria:

• age < 18 years

• open lung injuries

• instable injury of spine or cranium

• thoracic metal implants

• body mass index > 35

Related Conditions & MeSH terms

• Circulatory Failure
• Fluid Overload
• Fluid Responsiveness
• Respiratory Failure
• Respiratory Insufficiency
• Shock

Intervention

Other:
• Fluid Challenge
Infusion of a standardized amount of crystalloid solution (500 ml) to assess fluid responsiveness by means of changes in cardiac output, assessed by transpulmonary thermodilution.

Locations

Country	Name	City	State
Germany	University Medical Center Schleswig Holstein, Campus Kiel	Kiel	Schleswig-Holstein

Sponsors (1)

Lead Sponsor	Collaborator
University of Schleswig-Holstein

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in end-expiratory lung impedance (EELI)	To assess the effect of fluid challenge on EELI, the change in EELI during the fluid challenge will be measured by electrical impedance tomography and will be compared to the change in EELI during the last 15 minutes before start of the fluid challenge.	15-30 minutes
Secondary	Correlation between change in end-expiratory lung impedance and change in intrathoracic blood volume	We will assess the correlation between the change in end-expiratory lung impedance during infusion of 500 ml of crystalloid solution and the change in intrathoracic blood volume (assessed by transpulmonary thermodilution) during the same time period.	15-30 minutes
Secondary	Fluid responsiveness	We will investigate whether the ratio of cardiac-related impedance changes to ventilation-related impedance changes, measured by EIT at baseline (i.e. before start of fluid challenge), can predict fluid responsiveness, defined as an increase in stroke volume of greater or equal to 15% compared to baseline.	15-30 minutes