Exercise Capacity Under Various FiO2 and Oxygen Flow Rates Using HFNC

Respiratory Failure Clinical Trial

Official title: Examination of Exercise Capacity Under Various Oxygen Concentrations and Oxygen Flow Rates Using High Flow Nasal Cannula

Status Completed

Clinical Trial Summary

The purpose of this study is to compare the exercise capacity (6-min walking distance) under the following 4 conditions using High-flow nasal cannula (HFNC); 1. FIO2 value that the minimum SpO2 value in a 6-minute walking test (6MWT) is 86-88%, and a flow of 10 L/min 2. FIO2 value that the minimum SpO2 value in a 6MWT is 86-88%, and a flow of 40-50 L/min 3. FIO2 value that the minimum SpO2 value in a 6MWT is 92-94%, and a flow of 10 L/min 4. FIO2 value that the minimum SpO2 value in a 6MWT is 92-94%, and a flow of 40-50 L/min

Clinical Trial Description

In the pervious study, the investigators demonstrated that 4 weeks of training using both high FIO2 and high flow through an HFNC significantly improved the 6MWD compared with training using a 6 L/min nasal cannula. However, it was unclear whether the effects of pulmonary rehabilitation under HFNC were due to high FIO2, high flow rate, or a synergistic effect. It is also unknown whether there are differences in the effects of pulmonary rehabilitation under HFNC for each underlying disease. ;

Related Conditions & MeSH terms

• Exercise Capacity
• High-flow Nasal Cannula
• Respiratory Failure
• Respiratory Insufficiency

• NCT number: NCT04471220
• Study type: Interventional
• Source: National Hospital Organization Minami Kyoto Hospital
• Status: Completed
• Phase: N/A
• Start date: July 1, 2020
• Completion date: September 29, 2022