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NCT05715788 Clinical Trial

Prone Positioning vs. Prone Positioning and NO Inhalation in COVID-19 ARDS.

Respiratory Distress Syndrome Clinical Trial

Official title:
Prone Positioning Versus Prone Positioning and NO Inhalation in COVID-19 Associated Acute Respiratory Distress Syndrome.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05715788
Other study ID # ppv-vs-ppvno
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 21, 2022
Est. completion date December 2023

Study information
Verified date February 2023
Source Shanghai Zhongshan Hospital
Contact Ming Zhong, PhD
Phone ?(021) 6564 2662?
Email zhong.ming@zs-hospital.sh.cn
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigators aim to investigate the effects of prone positioning and prone positioning with NO inhalation for COVID-19 patients with ARDS.

Description:

The investigators aim to investigate the effects of prone positioning and prone positioning with NO inhalation for COVID-19 patients with ARDS. Patients with COVID-19-associated ARDS were ventilated in prone position with or without NO inhalation, the arterial blood gas (ABG) tests were performed at 16 hours after prone positioning.

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date December 2023
Est. primary completion date December 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Adult patients with COVID-19 associated ARDS Exclusion Criteria: - patients who have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Nitric oxide
Nitric oxide inhalation at 20 ppm
Behavioral:
• prone positioning
vatilation in prone position

Locations
Country Name City State
China Zhongshan Hospital, Fudan University Shanghai Shanghai

Sponsors (1)
Lead Sponsor Collaborator
Shanghai Zhongshan Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary P/F ratio P/F ratios in each group 16 hours
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