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Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)

Respiratory Distress Syndrome Clinical Trial

Official title:
Propofol and Remifentanil Versus Midazolam and Remifentanil as Premedication Allowing Very Early Extubation After Surfactant Treatment in Preterm Neonates With Respiratory Distress Syndrome

Clinical Trial Summary

The aim of the study is to compare the intubation conditions among propofol and remifentanil versus midazolam and remifentanil in premature neonates with respiratory distress syndrome. At the same time, to show the group of drugs that could let the neonates with no residual sedation after the use of surfactant (the possibility of the premature neonates to be readily extubated after the use of surfactant).

Clinical Trial Description

It has been demonstrated that remifentanil, due to it its very short context-sensitive, has an interesting potential for use in premature neonates with respiratory distress syndrome. Indeed, remifentanil allowed an adequate level of sedation and analgesia as well as rapid recovery after discontinuation. The aim of the present study was to compares the intubation conditions among propofol and remifentanil versus midazolam and remifentanil in premature neonates with respiratory distress syndrome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00797160
Study type Interventional
Source Federal University of Minas Gerais
Contact Yerkes P Silva, PhD
Phone 00553199933384
Email yerkesps@uol.com.br
Status Unknown status
Phase Phase 4
Start date August 2008
Completion date December 2009
View Details
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