Respiratory Diseases Clinical Trial
Official title:
Assessing the Biology of the Injured Lung - Version 1
Respiratory diseases are very common and are the third leading cause of death in England. As such, there is strong interest in understanding how respiratory disease occurs. This study intends to understand the changes that occur within diseased/injured lungs obtained from humans. The end goal of this will be to create new drugs to help treat these disorders. Diseased lungs will be obtained from patients receiving a lung transplant. Lungs will either be placed onto a heart-lung machine, or surgically cut in order to create a model of the lung that can be used experimentally in the laboratory. Using a heart-lung machine, lungs can be maintained outside of the human body for a maximum of 12 hours, allowing the direct assessment of the organ. Using this procedure, we aim to understand the processes that occur within a disease, as well as during repair. Using the model of the lung, we will look at how the body's immune system interacts within a diseased lung.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04461821 -
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents
|
||
| Recruiting |
NCT06267859 -
Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children
|
Early Phase 1 | |
| Completed |
NCT04386408 -
Evaluation of the Effect of a Combination of Plant Extracts (BSL_EP027) on the Incidence of Respiratory Infections
|
Phase 1 | |
| Recruiting |
NCT06229613 -
Exhaled Breath Aerosol for the Etiological Diagnosis of Respiratory Tract Infections: a Pilot Study
|
||
| Completed |
NCT02084043 -
In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation
|
N/A | |
| Completed |
NCT01113255 -
Validation of a Simulated Clinical Evaluation of Ventilators
|
Phase 2/Phase 3 | |
| Completed |
NCT00988000 -
Initial Specialist Telephone Consultation With New Patients in Secondary Care
|
N/A | |
| Completed |
NCT02723890 -
The Efficacy and Safety of Using the Novel Tyto Device
|
N/A | |
| Completed |
NCT00719784 -
Vibration Response Imaging in the Diagnosis of Pulmonary Disease
|
N/A | |
| Completed |
NCT00823056 -
The Effect of Probiotics on Infections in Toddlers
|
Phase 3 | |
| Recruiting |
NCT06366113 -
Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)
|
N/A | |
| Recruiting |
NCT05175313 -
Transthoracic Ultrasonography Findings and Their Relation to Spirometric Indices in Patients With Obstructive and Restrictive Respiratory Diseases
|
||
| Completed |
NCT02754947 -
Need for the Assessment and Consultation Team (ACT) Following Anesthetic Care
|
||
| Completed |
NCT01255592 -
Evaluation of the Effect of AZD5069 in Patients With Bronchiectasis
|
Phase 2 | |
| Completed |
NCT00840723 -
Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects
|
N/A | |
| Recruiting |
NCT02717650 -
The Alfred Step Test Exercise Protocol (A-STEP), for Adults With Cystic Fibrosis.
|
N/A | |
| Completed |
NCT01196533 -
A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters
|
N/A | |
| Completed |
NCT02406053 -
Oxidative Damage and Antioxidant Mechanisms in COPD
|
N/A | |
| Completed |
NCT01734629 -
Pulmonary Disease in Patients Referred for Coronary CT
|
N/A | |
| Completed |
NCT00532896 -
Impact of Weight Loss Following Bariatric Surgery on Pulmonary Function in Patients With Morbid Obesity
|
N/A |