Resectable Pancreatic Cancer Clinical Trial
Official title:
A Pilot Study of a Hedgehog Pathway Inhibitor (LDE-225) in Surgically Resectable Pancreas Cancer
We hypothesize that administration of LDE-225 in humans with pancreatic cancer will result
in inhibition of paracrine HH signaling in the pancreatic tumor stroma while having no
effect on autocrine signaling in the tumor cell compartment. Furthermore we hypothesize that
treatment with LDE-225 will result in changes in the tumor stroma (decreased desmoplasia,
increased vascularity) that will result in improved tumor blood flow.
The purpose of this study is to determine if, where and how LDE-225 works in pancreatic
cancer. A cancer cell's growth can depend on the cells and tissue around it. The cells and
tissue make chemical signals to influence the cancer's growth. This research study is
evaluating LDE-225 designed to interfere with one of the growth signals causing pancreatic
cancer growth.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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