Reperfusion Injury Clinical Trial
Official title:
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
NCT number | NCT03068689 |
Other study ID # | RIPC |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | December 1, 2017 |
Est. completion date | August 2023 |
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect of RIPC
Status | Recruiting |
Enrollment | 40 |
Est. completion date | August 2023 |
Est. primary completion date | August 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - Informed Consent as documented by signature (Appendix Informed Consent Form) - Kidney tumor (any entity, benign, malign) - Partial nephrectomy (any surgical technique, open, retroperitoneoscopic, transperitoneal, Da Vinci assisted) - 18 years of age - Sufficient perfusion of all 4 extremities - palpable distal pulses: A. radialis and A. dorsalis pedis or A.tibialis post. Exclusion Criteria: - Women who are pregnant - Significant peripheral arterial disease affecting upper and/or lower limbs or history of - Significant renal disease (GFR <15 ml/min/1.73m2) or undergoing haemodialysis - Concomitant therapy with glibenclamide or nicorandil (due to potential inference with RIPC) - Urothelial cancer - Acute Urinary tract infection - international normalized ratio (INR) >2 (haematoma risk at cuff site) |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital Basel, Clinic of Urology | Basel |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Basel, Switzerland |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Biomarker reduction | The study seeks primarily to determine the reduction of the biomarker concentration (Calprotectin and NGAL) in urine. Change in biomarkers will be measured at baseline, during 5 days after surgery and at timepoint month 3. | Baseline, 5 days and 3 months | |
Secondary | Acute renal failure | The secondary objective is to demonstrate the effect/reduction acute renal failure after RIPC as compared to the control group. Number of patients with acute renal failure will be compared between both groups. Acute renal failure will be assessed in the days after surgery (acute kidney failure) |
Baseline, 5 days, 3 Months | |
Secondary | Chronic renal failure | Number of patients with chronic renal failure will be compared between both groups. Chronic renal failure will be assessed in at baseline until timepoint month 3 (chronic kidney failure). |
Baseline, 3 Months | |
Secondary | Tubular damage in BOLD MRT | ? R2*-values in BOLD magnetic resonance tomography (MRT) will be compared between both groups. | Baseline, day 2 |
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