Clinical Trials Logo
  1. Home
  2. Reperfusion Injury
  3. NCT04316468
  4. Details
NCT04316468 Clinical Trial

Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation

Reperfusion Injury Clinical Trial

Official title:
Evaluation of Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT04316468
Other study ID # 20-001209
Secondary ID
Status Terminated
Phase
First received
Last updated
Start date March 10, 2020
Est. completion date April 8, 2024

Study information
Verified date April 2024
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Researchers are trying to improve the understanding of systolic function of the heart at the time of liver reperfusion in patients undergoing orthotopic liver transplantation.

Recruitment information / eligibility
Status Terminated
Enrollment 20
Est. completion date April 8, 2024
Est. primary completion date April 8, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age greater than 18 years - Undergoing primary orthotopic liver transplantation Exclusion Criteria: - Redo orthotopic transplantation - Acute or fulminant liver failure - Patient with pre-existing atrial fibrillation or hypertrophic cardiomyopathy - Patients with an abnormal preoperative stress test (EF <55%, areas of prior infarct, ongoing ischemia)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Mayo Clinic in Florida Jacksonville Florida

Sponsors (1)
Lead Sponsor Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Degree of change in cardiac strain Evaluate the degree of change to cardiac strain using speckle tracking echocardiography Up to 1 hour after graft reperfusion
Secondary Pattern of right and left ventricular strain Describe the pattern of right and left ventricular strain throughout the course of orthotopic liver transplantion. Up to 5 hours from the time of surgery start
See also
  Status Clinical Trial Phase
Completed NCT02251041 - Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL) Phase 2
Completed NCT01944605 - Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest N/A
Completed NCT00994981 - Magnesium Administration in Liver Transplantation and Reperfusion Injury Phase 4
Completed NCT00778323 - Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery Phase 1/Phase 2
Completed NCT00529607 - Diagnostics for the Reperfusion Injury Following MI N/A
Completed NCT02286544 - Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers Phase 1
Completed NCT02731651 - Effect of Pneumoperitoneum on Human Ovary N/A
Active, not recruiting NCT00189007 - Antenatal Allopurinol During Fetal Hypoxia Phase 3
Completed NCT01167569 - Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients Phase 4
Completed NCT00246740 - Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting Phase 2
Enrolling by invitation NCT05725694 - Acute Ischaemic STROKE: From LAboratory to the Patient's BED
Completed NCT00402506 - A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG Phase 3
Completed NCT03176823 - Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury N/A
Completed NCT02512640 - Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery N/A
Recruiting NCT05574296 - Hydrogen's Feasibility and Safety as a Therapy in ECPR Phase 1
Active, not recruiting NCT02127996 - GLP-1 Loading During Elective Percutaneous Coronary Intervention Phase 2
Suspended NCT02850471 - Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery Phase 1/Phase 2
Terminated NCT02394405 - Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Completed NCT00516711 - Role of Volatile Anesthetics for Hepatic Protection N/A
Not yet recruiting NCT05676957 - Reperfusion With Hypothermia in Acute Ischemic Stroke N/A