Renal Transplantation Clinical Trial
Official title:
Diagnostic Ability of Diffusion MRI and Diffusion Tensor in Renal Graft Biopsies: Pilot Study
While renal graft outcomes were really improved for the last decade, long time outcomes
remains stable. Indeed, at 10 years after transplantation, the renal graft survival rate
reaches 50%. The chronic allograft nephropathy is the main cause of renal graft loss. Other
features such as acute allograft rejection, delayed renal recovery and anti-human leukocyte
antigen (anti-HLA) antibodies are associated with poor renal graft survival prognosis. Renal
graft protocol biopsies at 3 and 12 months after transplantation are valuable to detect
precociously renal injuries at a reversible stage before clinical manifestation. However,
renal biopsy is an invasive examination with hemorrhagic risk. Diffusion MRI could be a
non-invasive diagnostic tool allowing the early detection of renal injuries, especially
allograft rejection without hemorrhagic risk. This tool could be applied routinely to the
renal allograft recipient in replacement of protocol biopsies.
Here, aim of this study is to correlate the results from diffusion MRI of renal graft with
pathologic findings from protocol renal graft biopsies.
In this view, the investigators include prospectively all recipients of renal
transplantation who beneficiate of a protocol renal graft biopsy without barrier to peform
MRI examination. Thus, the investigators exclude patients who are not be able to beneficiate
of a MRI examination and patient obstacle to renal graft biopsy.
Expected results are the Banff classification from the histopathologic analysis of biopsies.
The expected results for MRI examination are signal intensity, diffusive coefficient,
anisotropy fraction and change of the diffusion way. Next, the investigators search an
association between these features by statistical analysis (Wilcoxon test, Chi², Fisher,
Pearson or Spearman).
The investigators performed this study since 01/06/2014 and projected end-time to
01/06/2017.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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