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Renal Transplant clinical trials

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NCT ID: NCT05876507 Recruiting - Fatigue Clinical Trials

Effect of Progressive Exercise on Renal Transplant Patients

Start date: February 13, 2023
Phase: N/A
Study type: Interventional

The goal of this interventional study is to determine the effect of progressive relaxation exercises on the vital signs and fatigue levels of patients with renal transplantation.

NCT ID: NCT05632523 Recruiting - Renal Transplant Clinical Trials

Early Pharmacological and Immune Monitoring After Conversion to Belatacept in Renal Transplant Patients

EPIMAC-BELA
Start date: December 13, 2023
Phase:
Study type: Observational

Single-center, prospective, translational, clinical-biological, multidisciplinary study

NCT ID: NCT05156086 Recruiting - Renal Transplant Clinical Trials

Safety and Effectiveness of COVID-19 Vaccine in Kidney Transplant Recipients

CoVaKT
Start date: November 16, 2021
Phase:
Study type: Observational

The current study is a noninterventional prospective study examining the efficacy of additional dosage of the coronavirus disease 2019 (COVID-19) vaccine in kidney transplant recipients (KTRs).

NCT ID: NCT04874896 Recruiting - Renal Transplant Clinical Trials

Influence of the Intestinal Microbiota on the Clinical Course of Renal Transplantation

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

ACKGROUND: The development of new molecular techniques, in recent years, has increasing the knowledge of the composition and functionality of the intestinal microbiota. In the area of kidney transplantation, observational studies have described a change in the intestinal microbiota during the immediate post-transplantation period that seems to be related to the appearance of clinical outcomes such as diarrhea, repeated urinary tract infections, the need for adjustment of immunosuppressive treatment or acute rejection. However, intervention studies on this subject are necessary to determine how far the microbiota can influence in the development of these events. OBJECTIVE: To clarify the influence of maintaining the composition and functionality of the intestinal microbiota on post-transplant clinical outcomes such as diarrhea, urinary tract infections, kidney graft rejection and the need for dose adjustment of immunosuppressive therapy. MATERIALS AND METHODS: single-center, randomized, interventional pilot study with 50 deceased kidney donor transplant patients at low immunological risk. Each patient will be randomized at the time of inclusion in the study to one of the 2 branches of the study: 1) Intervention group: 25 patients who will receive a autologous fecal matter transfer during the first 6 months post-transplantation, 2) Control group: 25 renal transplant patients with the same characteristics who will not receive any type of intervention in addition to the immunosuppressive treatment indicated according to hospital protocol.

NCT ID: NCT04838288 Recruiting - Renal Transplant Clinical Trials

Cognitive Outcomes in Stable Renal Transplant Patients Switched fromTacrolimus to Envarsus XR™

OPERATOR
Start date: June 22, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess cognitive outcome and quality of life in stable renal transplant patients treated with twice daily tacrolimus at baseline and after switching to Envarsus XL. The study is designed to see if switching patients from Tacrolimus to Envarsus treatment improves cognitive function.

NCT ID: NCT04260828 Recruiting - Renal Transplant Clinical Trials

Efficacy and Safety Study of Aspirin for the Prevention of Renal Artery Stenosis in Renal Transplantation Recipients

Start date: February 28, 2020
Phase: Phase 4
Study type: Interventional

The anastomotic and peripheral stenosis of the transplanted kidney artery is one of the most important causes of graft failure in renal transplantation. The injury of vascular intima and the formation of microthrombosis may play a significant role in the stenosis of transplanted renal artery of recipients. Inhibiting this process with aspirin may protects against the stenosis of transplanted renal artery. This is a prospective, randomized, controlled, clinical trial to investigate the efficacy and safety of prevention of renal artery stenosis in recipients.

NCT ID: NCT03651492 Recruiting - Sleep Disorder Clinical Trials

Effects of Nocturnal Hypertension on Sleep Quality in Renal Transplant Recipients

Start date: June 1, 2017
Phase:
Study type: Observational

Nocturnal hypertension (i.e. blood pressure values >120/70 or 10% higher than diurnal values, as measured by ambulatory blood pressure monitoring, ABPM) is particularly frequent in renal transplant recipients (RTR), despite the use of antihypertensive drugs. Since RTR are also affected by several sleep disorders (like insomnia, restless legs syndrome, sleep apnoea) that frankly impair their quality of sleep (SQ), the aim of the present study is to ascertain whether a relationship exists between nocturnal hypertension and SQ. In fact, both nocturnal hypertension and sleep disorders may favour the onset or the progression of cardiovascular diseases, the first cause of death in RTR.

NCT ID: NCT03107858 Recruiting - Renal Transplant Clinical Trials

The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function

Start date: November 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Renal transplantation is now recognized as a treatment of choice for patients with chronic renal failure with end-stage renal disease. Renal transplantations are associated with better quality of life, better cost/benefit ratio, and possibly longer survival. Significant changes in blood pressure are common throughout the surgical procedure for kidney transplantation. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration.

NCT ID: NCT03016455 Recruiting - Renal Transplant Clinical Trials

B Cell Lymphocyte in Humoral Rejection and Alloimmunisation

BHL
Start date: June 2013
Phase: N/A
Study type: Observational

This study aims to better characterise B cell phenotype and functional abnormalities in kidney transplant patients producing donor specific antibody (DSA) and in those with chronic antibody mediated rejection (cAMR) and to search for a predictive tool (biomarker). The functional analysis will help to better understand B cell-dependant mechanisms implied in T cell proliferation and better target future treatments.

NCT ID: NCT02894606 Recruiting - Renal Transplant Clinical Trials

Influence of Thymoglobuline on Phenotypic and Functional Profiles of B Lymphocytes in Renal Transplant Recipients

THYMO B
Start date: February 2015
Phase: N/A
Study type: Observational

The investigators expect to better characterise B cell subpopulation and functional properties early after graft, to analyse effect of induction therapy (thymoglobulin versus basiliximab) on B cells, and to compare this B cell profiles with those obtained in our previous study in patients with chronic Antibody Mediated Rejection (cAMR)