Stone Clearance in Patients With Upper Ureteric Stones Using Extracorporeal Shock Wave Lithotripsy Compared With Extracorporeal Shock Wave Lithotripsy Combined With Tamsulosin Therapy

Renal Stone Clinical Trial

Official title:

Stone Clearance in Patients With Upper Ureteric Stones Using Extracorporeal Shock Wave Lithotripsy Compared With Extracorporeal Shock Wave Lithotripsy Combined With Tamsulosin Therapy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05725122
• Other study ID #: S23
• Status: Completed
• Phase: N/A
• Start date: February 1, 2018
• Est. completion date: December 31, 2021

Study information

• Verified date: February 2023
• Source: Services Hospital, Lahore
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Extracorporeal shock wave lithotripsy (ESWL) is the least invasive and effective treatment for upper ureteric stones with a stone clearance rate of 60-90%. Tamsulosin is an alpha-blocker widely used in urological practice to relax smooth muscle of the prostate and bladder neck. Its role as part of medical expulsion therapy for the treatment of patients with kidney and ureteric stones has proved to be of considerable success. However, its role in clearing upper ureteric stones as an adjunct to ESWL is controversial. Therefore, this study will be conducted to evaluate its role in stone clearance along with extracorporeal shock wave lithotripsy in patients with upper ureteric stones

Recruitment information / eligibility

• Status: Completed
• Enrollment: 82
• Est. completion date: December 31, 2021
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• single upper ureteric stone

• size ranging from 6-15 mm

• stones history less than 6 months

Exclusion Criteria:

• Patients with urinary tract infection

• multiple ureteric stones,

• presence of a ureteric stricture distal to the stone,

• previous unsuccessful ESWL,

• concomitant use of calcium channel blockers or alpha-adrenergic antagonists

• patients with abnormal coagulation profile

Related Conditions & MeSH terms

• Calculi
• Kidney Calculi
• Nephrolithiasis
• Renal Stone
• Ureteral Calculi
• Ureterolithiasis

Intervention

Procedure:
• Extracorporeal shock wave lithotripsy
Extracorporeal shock wave lithotripsy will given to the patients
• Extracorporeal Shock Wave Lithotripsy combined with Tamsulosin Therapy.
Extracorporeal Shock Wave Lithotripsy combined with Tamsulosin Therapy will be given to the patients

Locations

Country	Name	City	State
Pakistan	services Institute of Medical Sciences	Lahore	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
Services Hospital, Lahore

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	stone clearance	Number of patients cleared from ureteric stones	4 weeks