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NCT03865004 Clinical Trial

Combination Trial of Intravenous Paracetamol - Morphine for Treating Acute Renal Colic in Emergency Setting: An Optimum Treatment

Renal Colic Clinical Trial

Official title:
Paracetamol Plus Morphine in ED

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03865004
Other study ID # firatbektas
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date October 17, 2015
Est. completion date October 17, 2018

Study information
Verified date March 2019
Source Akdeniz University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This randomized, placebo-controlled trial evaluated the analgesic efficacy and safety of intravenous morphine-paracetamol combination and morphine-dexketoprofen combination morphine for the optimum treatment of renal colic. Combination of IV morphine and paracetamol is as effective and rapid as combination of IV Morphine and IV dexketoprophen for optimum treating of renal colic.

Recruitment information / eligibility
Status Completed
Enrollment 136
Est. completion date October 17, 2018
Est. primary completion date October 17, 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years to 55 Years
Eligibility Inclusion Criteria: Renal colic patients -

Exclusion Criteria: Not renal colic patients

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Paracetamol+Morphine
1gr paracetamol plus 0.1 mg/kg morphine were performed simultanously
• Dexketoprofen plus Morphine
Intravenous 75 mg Dexketoprofen plus 0,1 mg/kg morphine were performed simultanously
• Placebo plus Morphine
100 cc NaCl plus 0.1 mg/kg morphine were performed simultanously

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Akdeniz University

Outcome
Type Measure Description Time frame Safety issue
Primary pain reductions in VAS scores during the 60th and 90th minutes 60 minutes
Secondary Need for rescue analgesic 30 minutes
See also
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Recruiting NCT04169555 - "Point of Care" Ultrasound and Renal Colic N/A
Completed NCT04160520 - Pramipexole and Morphine for Renal Colic Phase 1/Phase 2
Not yet recruiting NCT04080973 - Metabolic Workup in Patients Suffering From Kidney Stone Disease and Osteopenia N/A
Completed NCT01979042 - Urinary Markers for Unilateral Kidney Obstruction N/A
Completed NCT03706404 - Renal Colic Fast Track Pathway in the Emergency Department. N/A
Completed NCT03638921 - 35RC17_8826_NEPHROPAIN Phase APRES : Interest of the Equimolar Oxygen Nitride Mixture (MEOPA) in the Treatment of Pain in Patients Presenting to the Emergency Department for Suspected Renal Colic: a Study BEFORE AFTER Phase 2
Completed NCT03665753 - Comparison of IV 10, 20, and 30mg for Renal Colic Pain in the ED Early Phase 1
Not yet recruiting NCT05150899 - Role of Antihistaminic in Acute Renal Colic Prevent Pain Recurrence and Expulsion of Ureteric Stone ≤ 1cm
Recruiting NCT03790514 - Heat Wrap for Renal Colic N/A
Completed NCT00646061 - Pain Control in Renal Colic Phase 1
Completed NCT05653401 - Treatment of Renal Colic in the Emergency Department: Comparison Between Magnesium Sulfate and Lidocaine. Phase 2
Not yet recruiting NCT02782273 - Morphine Versus Ketorolac in Renal Colic Phase 4
Completed NCT01352676 - Limit Computed Tomography (CT) Scanning in Suspected Renal Colic
Not yet recruiting NCT06412900 - Radiomics and Image Segmentation of Urinary Stones by Artificial Intelligence
Not yet recruiting NCT06342648 - Intracutaneous Sterile Water and Diclofenac Sodium Injections in Renal Colic N/A
Recruiting NCT03137498 - Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department Phase 4
Recruiting NCT01742689 - Analgesic Efficacy of Intranasal Desmopressin in Acute Renal Colic Phase 3
Completed NCT01546701 - Buprenorphine in Acute Renal Colic Pain Management Phase 4