Sorafenib Combined With Chemotherapy for Renal Collecting Duct Carcinoma

Status Completed

Clinical Trial Summary

The goal of this clinical research study is to learn the effectiveness of sorafenib combined with gemcitabine plus cisplatin in the treatment of patients with locally advanced or metastatic collecting duct carcinoma(CDC) of the kidney. The safety of each treatment will also be studied.

Clinical Trial Description

Collecting duct carcinoma(CDC) of the kidney is a rare and aggressive neoplasm of the distal collecting tubules for which there is no established treatment. Since the histology of collecting duct carcinoma is similar to that of urothelial carcinoma, a prospective phase II trial in France(2007) studied gemcitabine plus cisplatin as the first-line treatment of advanced CDC, resulting an effective rate of 26%. The targeted drugs can produce definite efficacy on renal clear cell carcinoma, but the data on targeted drugs for the treatment of renal advanced collecting duct carcinoma is limited. We sponsored this study based on the assumption that targeted drugs combined with chemotherapy can produce additive, positive effects in CDC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01762150
Study type	Interventional
Source	Beijing Cancer Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	June 2011
Completion date	June 2018

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