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Clinical Trial Summary

This is a Phase 1b/2a, open-label, multi-center, dose-escalation and safety/efficacy evaluation trial of Pexa-Vec plus Cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The trial consists of a dose-escalation stage, where the maximum feasible dose of Pexa-Vec in combination with Cemiplimab will be determined, followed by an expansion stage. During the expansion patients will receive Cemiplimab alone or in combination with Pexa-Vec, which will be administered either through intravenous (IV) or intratumoral (IT) injection.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03294083
Study type Interventional
Source SillaJen, Inc.
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date June 7, 2018
Completion date November 2023

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