Renal Artery Stenosis Clinical Trial
Official title:
A Prospective Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis
This study will use PBV technique to quantitatively assess the improvement of renal perfusion before and after endovascular treatment (EVT) of renal artery stenosis.
BACKGROUND: Renal artery stenosis (RAS) is one of the main reasons for secondary hypertension
and renal failure, which etiologies include atherosclerosis, fibromuscular dysplasia and
takayasu arteritis. Endovascular treatment under digital subtraction angiography (DSA) is an
option to treat this disease. However, the technical success of this procedure is mainly
based on morphology of its targeting renal artery without any quantified data towards renal
blood perfusion. Thus, this study will try to solve how renal blood perfusion changes before
and after endovascular treatment of renal artery stenosis.
DESIGN NARRATIVE:
This prospective cohort study will recruit patients with renal artery stenosis. PBV data will
be obtained before and after their endovascular treatments. The volume of target kidney and
its mean density of contrast from PBV data will be calculated as indicators for renal
perfusion. And the relation between the percentage of stenosis and renal perfusion will be
analyzed. The follow-up will last for one year. At 6-month and 12-month follow-up, DSA and
PBV acquisition protocol will be undertaken again to evaluate renal blood perfusion in the
long term.
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