Diagnostic Imaging Clinical Trial
Official title:
Interest of a Systematic One-year Monitoring by 18F-FDG PET-CT of Patients in Complete Remission of Malignant Lymphoma
In the study, we aimed to characterize the role of FDG PET/CT surveillance at 12 months of malignant lymphoma in asymptomatic patients after a first complete remission and to define a rational follow-up strategy.
Most aggressive lymphomas are sensitive to first-line immunochemotherapy and are in first
Complete Remission (CR) with initial therapy. CR significantly decreases the risk of
recurrence and increases survival. However, a cure is not guaranteed and approximately one
third of lymphoma patients have a relapse disease.
FDG PET/CT is a valuable noninvasive tool in the evaluation of lymphomas, especially to
differentiate viable lymphoma and fibrosis or necrosis in residual mass.
The majority of relapses are diagnosed based on clinical symptoms reported by patients. And
the role of FDG PET/CT for routine surveillance of patients after treatment is controversial.
However, many medical centers use routine follow-up FDG PET/CT in addition to physical
examination and laboratory analysis to detect subclinical relapse.
Thus, we can imagine a good timing to routine FDG PET/CT when the tumor burden is small in
the asymptomatic window.
Survival improvement for relapse detected by routine follow-up imaging is not clearly
established compared to diagnosis by clinical symptoms.
Several studies tried to assess the value of follow-up FDG PET/CT but population, type,
timing and duration of surveillance imaging was very heterogeneous.
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