Clinical Trials Logo

Reflux Esophagitis clinical trials

View clinical trials related to Reflux Esophagitis.

Filter by:

NCT ID: NCT01733810 Completed - Clinical trials for Gastroesophageal Reflux Disease

The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis

Start date: February 1, 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.

NCT ID: NCT01538849 Completed - Reflux Esophagitis Clinical Trials

Study to Investigate the Safety, Tolerability and Efficacy of YH4808 in Patients With Reflux Esophagitis

Start date: December 2012
Phase: Phase 2
Study type: Interventional

This study is to investigate the optimal clinical dose and administration methods of YH4808 in patients with reflux esophagitis by evaluating the safety and efficacy after YH4808 oral administration.

NCT ID: NCT01397084 Completed - Clinical trials for Gastroesophageal Reflux Disease

To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole

Start date: August 2011
Phase: Phase 4
Study type: Interventional

Administration of esomeprazole 20 mg to subjects who still had heartburn after receiving rabeprazole 10 mg once daily for at least 4 weeks will result in statistically significant improvement of heartburn after 8-week treatment.

NCT ID: NCT01381991 Completed - Clinical trials for Gastroesophageal Reflux Disease

The Efficacy of i-Scan for Detecting Reflux Esophagitis

Start date: July 2010
Phase: N/A
Study type: Interventional

Endoscopy is a widely used modality for the diagnosis and classification of Gastroesophageal reflux disease (GERD), and the extent of esophageal mucosal breaks on endoscopy can be assessed. However, there were some limitation in diagnosis of GERD using endoscopy 1. More than half of patients with GERD reveal no visible abnormality on conventional endoscopy, it is possible that minute mucosal changes are underestimated by conventional endoscopy due to the limitation of visual ability 2. In addition of uncertainty in detecting mucosal breaks, uncertainty in describing severity of mucosal injury can lead to inconsistency among interpreters. Interobserver agreement regarding diagnosis and classification of GERD using endoscopy is unsatisfactory to apply daily practice. Thus, the development of a new method to define the intra-esophageal injury for use in daily practice is a worthwhile endeavor and developed, such as narrow−band imaging (NBI), Fuji Intelligent Chromoen−doscopy (FICE) and i-scan. Among them, i-scan technology is the most recently developed image enhancing technology, which consists of three modes of image enhancement, i.e. surface enhancement (SE), contrast enhancement (CE), and tone enhancement (TE). Thus, the investigators examined the hypothesis that i-scan can improve the detection rate of reflux esophagitis and inter-observer agreement between endoscopists compared with conventional white light (WL) endoscopic examination.

NCT ID: NCT01008696 Completed - Reflux Esophagitis Clinical Trials

An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis

Start date: May 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the treatment effects of rabeprazole and lansoprazole depending on the genotyping (process of determining the genetic constitution) of CYP2C19 in treating reflux esophagitis (caused by gastroesophageal reflux; deterioration of the protective lining on the inner wall of the lower esophagus); and to evaluate the cure rate of reflux esophagitis on endoscopy (a thin flexible tube with a microscopic camera at the end which is passed down your throat into the esophagus, stomach, and duodenum) after treatment with rabeprazole and lansoprazole.

NCT ID: NCT00859287 Completed - Reflux Esophagitis Clinical Trials

Omepral® Tablets Special Clinical Experience Investigation in Patients With Erosive Esophagitis

OMAREE
Start date: June 2007
Phase: N/A
Study type: Observational

This open label, non-interventional study is to compare the efficacy of Omepral® tablet and any other treatments excepting proton pump inhibitors (PPIs) for the treatment of various type of acid reflux related symptoms in patients with reflux esophagitis.

NCT ID: NCT00634114 Completed - Reflux Esophagitis Clinical Trials

Reflux Esophagitis Phase III Study (Maintenance Treatment)

Start date: January 2008
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the efficacy of esomeprazole 20 mg once daily for 24 weeks on maintenance of Reflux Esophagitis in patients with healed reflux esophagitis in comparison with omeprazole 10 mg once daily and esomeprazole 10 mg once daily by assessment of presence/absence of recurrence of Reflux Esophagitis throughout the treatment period (from the randomisation to the treatment completion) according to the Los Angeles classification.

NCT ID: NCT00633932 Completed - Reflux Esophagitis Clinical Trials

Reflux Esophagitis Phase III Study (Initial Treatment)

Start date: December 2007
Phase: Phase 3
Study type: Interventional

This study is to evaluate the efficacy of esomeprazole 20 mg once daily and 40 mg once daily for 8 weeks on healing of Reflux Esophagitis in patients with reflux esophagitis in comparison with omeprazole 20 mg once daily by assessment of presence/absence of Reflux Esophagitis at Week 8 according to the Los Angeles classification .

NCT ID: NCT00586963 Completed - GERD Clinical Trials

Proton Pump Inhibitor (PPI) Therapy for Newly Diagnosed Esophagitis

EE
Start date: January 2008
Phase: N/A
Study type: Observational

This study is being done to for two reasons: - To learn about the effects (good and bad) esomeprazole (an FDA approved drug for reflux esophagitis) has on your esophagus when taken correctly. - To learn about the quality of life changes (good and bad) you may experience with this medication.

NCT ID: NCT00206180 Completed - Clinical trials for Gastroesophageal Reflux Disease

NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis

Start date: June 2004
Phase: Phase 4
Study type: Interventional

The purpose of this study is to decide if controlling stomach acid is related to healing of erosive esophagitis after treatment with esomeprazole magnesium (NEXIUM®) 10 mg and 40 mg once daily.