Recurrent Rectal Cancer Clinical Trial
Official title:
Phase II Study Of Gleevec (Imatinib Mesylate Formerly Known As(STI571) (NSC #716051) In Patients With Colorectal Cancer Stage IV
Phase II trial to study the effectiveness of imatinib mesylate in treating patients who have stage IV colorectal cancer. Imatinib mesylate may interfere with the growth of tumor cells by blocking certain enzymes necessary for cancer cell growth
PRIMARY OBJECTIVES:
I. To determine response to Gleevec (Imatinib Mesylate) in patients with metastatic
colorectal cancer and with c-Kit, Arg, Abl, or PDGF-R expression.
II. To determine the side effects of Imatinib Mesylate in patients with colorectal cancer.
III. To study the biologic effects of Imatinib Mesylate on the c-Kit and PDGF-R system and
downstream signaling in metastatic colorectal cancer.
OUTLINE:
Patients receive oral imatinib mesylate twice daily. Treatment continues for 8 weeks in the
absence of disease progression or unacceptable toxicity. Patients with stable disease or
better continue therapy until disease progression or 1 year after complete response.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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