Niraparib Combined With Radiotherapy in rGBM

Status Recruiting

Clinical Trial Summary

Thirty patients were enrolled in this study, mainly patients with first recurrence of glioblastoma, and the requirement is that they can receive secondary radiotherapy. Regardless of whether the patient has received a second operation or the MGMT promoter is methylated, they can be included in this study. After enrollment, patients were given niraparib 300mg/day (body weight ≥77Kg and baseline platelet count ≥150,000/µL) or 200mg/day (body weight <77Kg or baseline platelet count <150,000/µL), combined with radiotherapy (total dose 55Gy), follow-up Time 1 year. Until the patient has disease progression or intolerance or voluntarily withdraw from the study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04715620
Study type	Interventional
Source	Tianjin Huanhu Hospital
Contact	Wei Jiang
Phone	+86 22 59065906
Email	wjianghh@163.com
Status	Recruiting
Phase	Phase 2
Start date	January 2021
Completion date	January 2023

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