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CD147-CART Cells in Patients With Recurrent Malignant Glioma.

Recurrent Glioblastoma Clinical Trial

Official title:
A Clinical Study to Investigate the Safety, Tolerance and Efficacy Evaluation of Single-centre, Open-label of Local Treatment of CD147-CART in Recurrent Glioblastoma.

Clinical Trial Summary

This is a single-center, single-arm, open label and dose escalation clinical study of anti-CD147 CART cells in patients with recurrent malignant glioma.

Clinical Trial Description

Patients autologous T cells are activated and then engineered to express chimeric antigen receptors (CARs) specific for CD147(CD147-CART). CAR-T cells are expanded in culture and returned to the patient by Ommaya Reservoir at specific cell doses. Three CD147-CART doses patient are planned at 1-week intervals. Serum cytokine level and CAR-T cell number will be measured in whole treatment session. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04045847
Study type Interventional
Source Xijing Hospital
Contact Zhinan Chen, PhD
Phone 029-84774547
Email znchen@fmmu.edu.cn
Status Recruiting
Phase Early Phase 1
Start date May 30, 2019
Completion date May 30, 2022
View Details
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