Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04500405 |
| Other study ID # |
202003113RINB |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
May 31, 2020 |
| Est. completion date |
August 31, 2023 |
Study information
| Verified date |
January 2023 |
| Source |
National Taiwan University Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
In the Emergency Department (ED), patients with acute diverticulitis usually present with
acute abdominal pain. Sometimes, or mostly, it is an exclusive diagnosis, meaning that the
diagnosis would be made after other emergent and acute abdomens are excluded. The recurrent
diverticulitis cost medical burden. The studies focusing on potential risk factors of
recurrent diverticulitis, especially for those after an episode of acute diverticulitis, are
limited.
Description:
Diverticular disease of the colon is common in industrial countries and has significant
impact on patient health as well as health care cost. It is common in both Western countries
and some Asian countries. For example, in the past, colonic diverticulosis was rare in Japan;
with detection rates as low as approximately 2% in 1960. The detection rate increased to
approximately 20% in the 1980s and 1990s. Studies have reported that increasing rates of
diverticulosis are caused by westernization of the diet in Asian countries and are becoming a
medical concern. Diverticular disease-associated hospital admissions have risen steeply in
the recent past, which are not completely accounted for by the increasingly aging population
of western countries. Approximately 130,000 hospitalizations occurring every year in the
United States are attributable to diverticular disease. An analysis of the age-adjusted
hospitalization rate of diverticulitis in the United States showed an increase from 62 per
100,000 in 1998 to 76 per 100,000 in 2005. These admission rates increased most in younger
patients (< 45 years old) and have remained unchanged in patients older than 65 years. In
spite of low mortality rate in patients with acute diverticulitis, moderate to severe
comorbidities occur in specific patient group.
Painter and Burkitt hypothesized it in their article in 1960s and 1970s. They based their
hypothesis on the observation that individuals in different geographic locations such as
western industrialized countries versus those in developing countries were noted to have
different rates of prevalence. They postulated that those in industrialized nations tended to
eat processed food that was low in fiber compared with individuals in Africa and Asia, where
the disease was previously unknown.
The USA Health Professional study showed a higher risk of diverticulitis in men with higher
body mass index (BMI), waist-to-hip ratio and waist circumference [8]. Obesity also
significantly increases costs associated with management of the disease and its complications
[9]. The effect of obesity on the risk of recurrent diverticulitis is unknown.
In the Emergency Department (ED), patients with acute diverticulitis usually present with
acute abdominal pain. Sometimes, or mostly, it is an exclusive diagnosis, meaning that the
diagnosis would be made after other emergent and acute abdomens are excluded. The recurrent
diverticulitis cost medical burden. The studies focusing on potential risk factors of
recurrent diverticulitis, especially for those after an episode of acute diverticulitis, are
limited.
This is a retrospective cohort study conduct from Oct 2008 to Sep 2018. The patients were
recruited from National Taiwan University Hospital (NTUH), NTUH Hsin-Chu Branch (HCH), and
NTUH Yun-Lin Branch.
