PR in Endoscopic LAR for Rectal Cancer

Status Recruiting

Clinical Trial Summary

The anastomotic leakage remains the major early complication after laparoscopic anterior resection(LAR) for medium & low rectal cancer. Pelvic floor reconstruction (PR) is a key step in various standard resections for open radical rectal cancer surgery, which was considered to be helpful for decreasing the rate of leakage. However, PR in endoscopic LAR surgery is not routine practice and remains controversial. The purpose of this study is to evaluate the efficacy of PR during LAR for mid/low rectal carcinoma, especially in preventing anastomotic leakage.

Clinical Trial Description

Eligible patients with rectal cancer will be randomly assigned to group with pelvic floor reconstruction(PR) versus group without pelvic floor reconstruction(NPR). We want to investigate the rate of anastomotic leakage and re-operation between the two groups, some other relevant outcomes will be concerned all the same. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04078828
Study type	Interventional
Source	Southwest Hospital, China
Contact	Tang Bo, MD
Phone	+862368754167
Email	tangtbo@sina.com
Status	Recruiting
Phase	N/A
Start date	September 1, 2019
Completion date	April 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT01227239` - Preoperative S-1/OHP With Radiation Therapy for Low-lying Rectal Carcinoma in Neo-adjuvant Setting	Phase 1/Phase 2
Recruiting	`NCT01459328` - Resource-Sparing Curative Treatment for Rectal Cancer	Phase 3
Terminated	`NCT02797405` - Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay	N/A
Completed	`NCT01751516` - PET/MRI as a Predictor of Response to Pre-op Chemoradiation in Resectable Rectal Cancer: a Pilot Study
Terminated	`NCT01111292` - Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia	Phase 1/Phase 2
Completed	`NCT00682786` - Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma	Phase 2
Completed	`NCT02000050` - Phase II Study of Up-front Chemotherapy and Neo-adjuvant Short-course Radiotherapy for Resectable Rectal Carcinoma (COLORE)	Phase 2
Recruiting	`NCT04749108` - Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma	Phase 2/Phase 3
Active, not recruiting	`NCT01696981` - Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)	N/A
Active, not recruiting	`NCT01899547` - Laparoscopy-Assisted Surgery for Carcinoma of the Low Rectum	N/A
Completed	`NCT01333709` - Multicenter Phase 2 Trial: a Tailored Strategy for Locally Advanced Rectal Carcinoma	Phase 2
Recruiting	`NCT04848311` - Indocanine Green as Tracer for Lymph Nodes Dissection in Station 253	N/A
Not yet recruiting	`NCT02770911` - Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer	Phase 3
Active, not recruiting	`NCT02432963` - Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy	Phase 1
Active, not recruiting	`NCT04505553` - Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer	Phase 2
Completed	`NCT01372007` - Influence of Somatuline Autogel 120mg on Post-operative Drainage After Total Mesorectum Excision for Rectumcarcinoma	Phase 3
Active, not recruiting	`NCT02817126` - Robot-assisted Versus Laparoscopic Surgery for Mid/Low Rectal Cancer	N/A
Completed	`NCT02551237` - Neoadjuvant Treatment for Advanced Rectal Carcinoma	Phase 3
Active, not recruiting	`NCT04713618` - Changes in Pelvic Health, Sexual Function, and Quality of Life in Women With Pelvic Cancer Undergoing Radiation Therapy
Recruiting	`NCT02268006` - IMRT-SIB and Capecitabine in Preoperative Rectal Cancer Treatment	Phase 2