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NCT05607186 Clinical Trial

Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian Institute

Rectal Cancer Clinical Trial

Official title:
Outcomes of Neoadjuvant Therapy for Rectal Cancer in a Tertiary Asian

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05607186
Other study ID # 2019/2342
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2011
Est. completion date December 31, 2019

Study information
Verified date October 2022
Source Singapore General Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This is a retrospective cohort study that aims to evaluate the correlation of magnetic resonance tumour regression grade (mrTRG) and pathological TRG (pTRG) of locally advanced rectal cancer after neoadjuvant long course chemoradiotherapy as well as the prognostic value of mrTRG on survival.

Recruitment information / eligibility
Status Completed
Enrollment 59
Est. completion date December 31, 2019
Est. primary completion date December 31, 2016
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Rectal cancer - At least 1 high risk feature on MRI - Undergo long course neoadjuvant chemoradiotherapy (LCCRT) Exclusion Criteria: - metastatic disease - Patients who undergo short course radiotherapy - Patients without a repeat MRI after completion of LCCRT

Study Design

Related Conditions & MeSH terms

Intervention

Radiation:
• neoadjuvant long course chemoradiotherapy
neoadjuvant long course chemoradiotherapy consist of radiosensitizing 5FU or capecitabine and 50.4 Gy in 28 fractions over 5 weeks

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Singapore General Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary Correlation between mrTRG and pTRG Between 1 Jan 2011 to 31 Dec 2016
Secondary Prognostic value of mrTRG on survival outcomes of rectal cancer patients Between 1 Jan 2011 to 31 Dec 2016
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