Radiotherapy; Complications Clinical Trial
Official title:
Hypofractionated Radiotherapy and Concurrent Cisplatin for Locally Advanced Head and Neck Cancer: A Feasibility Trial
The aim of this study is to evaluate the feasibility of hypofractionated radiation therapy and concomitant chemotherapy with cisplatin for locally advanced head and neck cancer in a high volume brazilian center.
To evaluate if concomitant cisplatin and hypofractionated radiation therapy wold be feasible
in a brazilian population.
Patients eligibility criteria:
older than 18 years old Biopsy proven squamous cell carcinoma of oropharynx, larynx and
hypopharynx. Stage III an IV, with no distant metastasis. ECOG performance status 0-2.
Adequate renal and liver function. Good status for radical treatment
Treatment considered feasible if:
1. Patient receive at least 90% of radiation dose (18 of 20 fractions of 275cGy)
2. Patients receive at least 3 of 4 weekly cycles of cisplatin (35mg/m2)
3. Treatment length up to 35 days.
4. Grade 4 toxicity lower than 25%
;
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