Radical Prostatectomy Clinical Trial
Official title:
Post-Prostatectomy Linac-Based Ultrahypofractionated Radiotherapy for Patients With Localized Prostate Cancer: A Treatment Feasibility and Outcomes Study
Radical prostatectomy is a common treatment for localized prostate cancer. More than 30% of men who undergo surgery will subsequently develop recurrence, particularly in patients with adverse features where the risk may be even higher. Recurrence typically manifests as a rise in serum-level of prostate-specific antigen (PSA), referred to as biochemical recurrence. Post-operative radiotherapy is a potentially curative option for many patients, as shown in multiple prior randomized studies. A standard course of post-operative radiation requires 6 to 6 and half weeks of treatment, 5 days a week; however, new high-precision radiation techniques with image guidance, termed stereotactic body radiotherapy (SBRT), can deliver an equivalent or higher dose of treatment in 5 visits. Our group, amongst others, have demonstrated in previous studies, that the new 5-treatment technique was safe, convenient and effective in patients with intact prostates. Currently, limited data exists on this approach after prostatectomy. This study will be one of the first to assess the side effect profile and efficacy of SBRT in patients with localized prostate cancer who are considered candidates for post-prostatectomy radiation.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT04059341 -
Early Extracorporeal Shockwave Therapy for Erectile Dysfunction in Radically Prostatectomised Men.
|
N/A | |
Recruiting |
NCT04687969 -
Multimodal Machine Learning Characterization of Solid Tumors
|
||
Recruiting |
NCT05625048 -
Urinary Incontinence After Radical Prostatectomy
|
N/A | |
Recruiting |
NCT05558007 -
Safety and Efficacy Evaluation of BZ371A Topically Applied on Prostatectomized Patients
|
Phase 2 | |
Completed |
NCT05332340 -
Safety, Tolerability and Pharmacokinetics (PK) Evaluation of BZ371A, Topically Administered
|
Phase 1 | |
Enrolling by invitation |
NCT04399876 -
Pilot Study of an Implantable Microdevice for Evaluating Drug Responses in Situ in Prostate Cancer
|
Phase 1 | |
Active, not recruiting |
NCT01540656 -
Mechanical Nerve Stimulation in the Treatment of Post Prostatectomy Incontinence
|
Phase 3 | |
Terminated |
NCT01220427 -
Micro-RNA Expression Profiles in High Risk Prostate Cancer
|
N/A | |
Not yet recruiting |
NCT06351579 -
Data Collection Post Radical Prostatectomy
|
||
Completed |
NCT03639389 -
Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy
|
Phase 3 | |
Completed |
NCT04862533 -
Effect of Beta-alanine and Pelvic Floor Muscle Training on Urinary Incontinence After Radical Prostatectomy (BELA)
|
N/A | |
Completed |
NCT03587402 -
Effects of Transcutaneous Perineal Stimulation Versus Anal Stimulation
|
N/A | |
Withdrawn |
NCT03338712 -
Micro-RNA Expression Profiles in Localised Prostate Cancer
|
||
Recruiting |
NCT06085664 -
A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy
|
Phase 1/Phase 2 | |
Terminated |
NCT00955929 -
Pharmacological Penile Rehabilitation in the Preservation of Erectile Function Following Bilateral Nerve-Sparing Radical Prostatectomy
|
N/A | |
Completed |
NCT00953277 -
Study of Nerve Reconstruction Using AVANCE in Subjects Who Undergo Robotic Assisted Prostatectomy for Treatment of Prostate Cancer
|
Phase 4 | |
Recruiting |
NCT06275945 -
Feasibility Study of A VoRo UrologIc ScaffolD (ARID)
|
Phase 2 | |
Completed |
NCT04587505 -
Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy.
|
Phase 4 |