Radiation Toxicity Clinical Trial
Official title:
Relationships Between the Changes of Skin Temperature and Radiation Skin Injury
the main purpose of the present study was threefold: (1) to describe the thermographic response after radiation; (2) to investigate whether there was a significant temperature change over time and among the different radiation-dermatitis score; and (3) to test if temperature change could be used to predict the development of radiation-induced skin injury in the incipient stage.
Radiation skin injury (RSI) is a frequent adverse reaction reported encountered by patients
undergoing radiotherapy, occurring in about 87%-95% of irradiated patients and is
characterized by swelling, redness, pigmentation, ulceration, fibrosis, pain, warmth, burning
and itching of the skin. RSI has an effect on the level of discomfort experienced and the
quality of life of patients, and may require interfering with radiation schedule and complex
surgical reconstruction especially when combined with molecular targeted therapy. However,
evaluation of RSI is not straightforward. There is no standard instrument for objective
clinical evaluation of the severity of radiation skin injury.
Previous studies have shown that radiation leads to the development of cutaneous vasculature
and generation of an inflammatory response, which will increased skin temperature. The skin
temperature change due to laser or thermal injury has been measured in many studies with
temperature and time as predictors of skin damage.
The most frequent method of skin temperature measurement has been the Infrared thermography.
Consequently, the changes in the difference of skin temperature (DST) may be used as an
objective, quantitative, and functional surrogate measure to determine and predict RSI.
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