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Radiation-Induced Xerostomia clinical trials

View clinical trials related to Radiation-Induced Xerostomia.

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NCT ID: NCT06414161 Recruiting - Clinical trials for Radiation-induced Xerostomia

Management of Radiotherapy-related Xerostomia With Green Tea and Peppermint

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this study is to evaluate the clinical effectiveness of a mix of (green tea and peppermint) mouth rinse using the subjective dry mouth score as a primary objective and to assess the effect of that mix on the salivary flow rate and objective dry mouth score as a secondary objective.

NCT ID: NCT06413550 Recruiting - Clinical trials for Radiation-induced Xerostomia

The Efficacy of Hibiscus Sabdariffa in Xerostomia

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this [ type of study: Clinical trial] is to test effectiveness of Hibiscus Sabdariffa L. mouth rinse using the subjective dry mouth score as a primary objective and to assess the effect of that mix on the salivary flow rate and objective dry mouth score as a secondary objective.

NCT ID: NCT05060341 Active, not recruiting - Clinical trials for Radiation-induced Xerostomia

Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia

Start date: November 12, 2020
Phase:
Study type: Observational

This study is a long-term follow-up study for patients who have been administered AAV2hAQP1 in the Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity in Subjects with Radiation Induced Parotid Gland Hypofunction and Xerostomia

NCT ID: NCT05020067 Completed - Clinical trials for Nasopharyngeal Carcinoma

Impact on Xerostomia for Nasopharyngeal Carcinoma Patients Treated With or Without Superficial Parotid Lobe-sparing Intensity-modulated Radiotherapy

Start date: January 12, 2018
Phase: Phase 2
Study type: Interventional

This is a prospective phase II clinical randomized controlled study, the purpose of this study is to assess whether superficial parotid lobe-sparing intensity-modulated radiotherapy (SPLS-IMRT) can decrease the incidence of xerostomia versus conventional IMRT (C-IMRT) in NPC patients.

NCT ID: NCT03035825 Completed - Dry Mouth Clinical Trials

Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

This randomized control trial aims to investigate the efficacy of oral moisturizing jelly in head and neck cancer patients with xerostomia.

NCT ID: NCT02589938 Completed - Clinical trials for Head and Neck Cancer

Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer

ACUPUNCTURE
Start date: November 11, 2012
Phase: N/A
Study type: Interventional

This study is being done to find out what effects, good and/or bad, acupuncture has on participants and their xerostomia caused by radiation therapy for the treatment of the cancer.

NCT ID: NCT02446249 Active, not recruiting - Clinical trials for Squamous Cell Head and Neck Cancer

Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction

Start date: May 4, 2015
Phase: Phase 1
Study type: Interventional

Background: - Radiation can cause the parotid salivary glands to make less saliva (dry mouth). This can cause problems like infections and tooth decay. Researchers hope a new drug can help people with dry mouth caused by radiation. Objectives: - To examine the safety of AAV2hAQP1 gene therapy. To see if the drug increases saliva in people whose parotid glands have had radiation. Eligibility: - People at least 18 years of age with a history of radiation therapy for head and neck cancer. Design: Participants will be screened in 2 visits with: - medical history - physical exam - scans of the head, neck, and chest - intravenous administration of glycopyrrolate to stop saliva - saliva collections - sialogram which is a procedure in which a substance is injected in the parotid gland and X-rays are taken. - non-drug infusion - a small piece of skin being taken 3-5-day hospital stay: Participants will receive the gene infusion. The AAV2hAQP1 will be in a solution in a syringe. It will be slowly pushed into the parotid gland through the parotid duct, an opening in the mouth near the second upper molar tooth. 10 outpatient visits over 3 years. These may include: - repeats of selected screening tests, including saliva collection - blood and urine tests - oral and dental examinations - head and neck exams, including the use of a thin scope to see the back of the throat - questionnaires - a small piece of parotid tissue being taken by either a small scope through the parotid duct or by a small needle guided by ultrasound - scans of the head and neck. For some, contrast will be injected in a vein - completion of a diary about how the participant feels between visits - swabs of teeth and gums to assess the microbiome of the mouth

NCT ID: NCT01885065 Completed - Cancer Clinical Trials

Efficacy of Novel Edible Gel-based Artificial Saliva in Cancer Patients

Start date: July 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether continuous use of edible, gel-based artificial saliva in cancer patients with dry mouth problems will reduce signs and symptoms of dry mouth and improve quality of patients' saliva.

NCT ID: NCT01195233 Completed - Clinical trials for Radiation-Induced Xerostomia

Comparative Analysis of BioXtra on Xerostomia

BioXtra
Start date: July 2010
Phase: Phase 2
Study type: Interventional

The present study compared the efficacy of BioXtra spray and mouth rinse in the relief of radiotherapy-induced xerostomia in patients referred to Cancer Institute, Tehran Imam Khomeini Hospital.

NCT ID: NCT00682747 Terminated - Clinical trials for Radiation-induced Xerostomia

Hyperbaric Oxygen for the Treatment of a Dry Mouth Which Occurred After Radiotherapy

Start date: May 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether hyperbaric oxygen is effective in the treatment of a dry mouth that occured after radiotherapy for head and neck tumours.