Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether bacterial decolonization of the nares prior to treatment with radiotherapy (RT) for patients with nasopharyngeal carcinoma, can prevent high-grade radiation-induced oral mucositis (RIOM) and improve quality of life. This study is being conducted because a randomized clinical trials form Yana Kost et al. have found bacterial decolonization in the nose prior to initiation of RT was effective for prevention of acute radiation dermatitis. Patients in the treatment arm will receive pretreatment with mupirocin ointment to the nares while patients in the control arm will receive standard of care treatment. Bacterial cultures will be taken from the nares and mouth, and participants will also complete a quality of life questionnaire before and after RT.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05893810
Study type	Interventional
Source	Jiangxi Provincial Cancer Hospital
Contact	Tianzhu Lu, PhD
Phone	8615270186250
Email	lutianzhu2008@163.com
Status	Recruiting
Phase	Phase 3
Start date	July 1, 2023
Completion date	December 31, 2024

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