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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06186921
Other study ID # Postendo pain Intraligamentary
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date December 2, 2023
Est. completion date March 3, 2024

Study information

Verified date December 2023
Source Jamia Millia Islamia
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will aim to evaluate postoperative pain after intraligamentary injections of dexamethasone (4mg/ml), diclofenac sodium (25mg/ml), 0.5% bupivacaine and 2% lidocaine given to the patients with symptomatic irreversible pulpitis after completion of the first appointment. Objectives: 1. To evaluate postoperative pain in patients receiving intraligamentary injections of either dexamethasone (4mg/ml), diclofenac sodium (25mg/ml), 0.5% bupivacaine or 2% lidocaine. 2. To compare the postoperative pain in different groups.


Description:

The patients will receive a primary Inferior alveolar nerve block injection using 1.8 mL of 2% lidocaine with 1: 80 000 epinephrine using a direct Halsted approach. The needle will be inserted until bony resistance is felt. After reaching the target area, aspiration will be performed, and the solution will be deposited over 60 seconds. After 10 minutes, the patients will be asked about the lip numbness. Patients without profound lip numbness will be excluded from the study since the block will be considered as 'missed'. A conventional access opening will be initiated after isolation with a rubber dam. After endodontic instrumentation and placement of temporary restoration, the patients shall receive intraligamentary injections of dexamethasone (4mg/ml), diclofenac sodium (25mg/ml), 0.5% bupivacaine, and 2% lidocaine. The patients will be randomly allocated to treatment groups with the help of an online random generator. The presence of postoperative pain (using Heft Parker visual analog pain scale) will be assessed at 2 hours, 6 hours, 24 hours, and 72 hours after treatment. The pain score proforma shall be collected at the subsequent visit.


Recruitment information / eligibility

Status Recruiting
Enrollment 140
Est. completion date March 3, 2024
Est. primary completion date March 3, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria: - Symptomatic carious exposed mandibular first or second molars. - Positive and prolonged response to thermal sensitivity tests and electric pulp tests. - Vital coronal pulp on access cavity preparation. - American Society of Anesthesiologists class I or II medical history. - Ability to understand the use of pain scales. Exclusion Criteria: - Active pain in more than 1 tooth - Teeth with fused roots. - Radiographic evidence of an extra root. - Large restorations with overhanging margins. - Full crowns or deep periodontal pockets. - Known allergy or contraindications to any content of the local anesthetic solution or NSAIDs - History of known or suspected drug abuse. - Taking any drugs which could affect the pain perception, e.g, opioids, antidepressants, anticonvulsants, muscle relaxants, anxiolytics, sedatives, NSAIDs. - Pregnant or breastfeeding patients. - Patients with asthma, gastric ulcers, and bleeding disorders.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Dexamethasone
After endodontic instrumentation and placement of temporary restoration, the patients shall receive intraligamentary injections.

Locations

Country Name City State
India Faculty of Dentistry, Jamia MIliia Islamia New Delhi

Sponsors (1)

Lead Sponsor Collaborator
Jamia Millia Islamia

Country where clinical trial is conducted

India, 

Outcome

Type Measure Description Time frame Safety issue
Primary Post operative pain The presence of postoperative pain (using Heft Parker visual analog pain scale) will be assessed at 2 hours, 6 hours, 24 hours and 72 hours after treatment. 2 hours, 6 hours, 24 hours and 72 hours after treatment
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